Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 1/20 | 0.41 |
| ▸ | MMP12 | P39900 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL771907 | 0.99 | PRKCA (0.41) | PRKCAMMP12SCN9AALDH1A1USP2 | |
| SCHEMBL12428662 | 0.94 | SCN9A (0.39) | PRKCAMMP12SCN9AALDH1A1USP2 | |
| Hydrochloric Acid SCHEMBL773003 | 0.94 | SCN9A (0.38) | PRKCAMMP12SCN9AALDH1A1USP2 | |
| SCHEMBL12428587 | 0.90 | PRKCA (0.40) | PRKCAMMP12SCN9AALDH1A1USP2 | |
| SCHEMBL12427666 | 0.90 | SCN9A (0.40) | PRKCAMMP12SCN9AALDH1A1USP2 | |
| Hydrochloric Acid SCHEMBL771450 | 0.90 | PRKCA (0.40) | PRKCAMMP12SCN9AALDH1A1USP2 | |
| SCHEMBL12428590 | 0.90 | PRKCA (0.42) | PRKCAMMP12SCN9AALDH1A1USP2 | |
| SCHEMBL10283208 | 0.89 | PRKCA (0.41) | PRKCAMMP12SCN9ANR1I2KDM4E | |
| Hydrochloric Acid SCHEMBL772246 | 0.89 | PRKCA (0.42) | PRKCAMMP12SCN9AALDH1A1USP2 | |
| SCHEMBL803980 | 0.89 | SCN9A (0.38) | PRKCAMMP12SCN9AALDH1A1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7977331-B1 | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor | JAPAN TOBACCO INC. (JP) | 2011-07-12 | — | — | US | disclosed |
| US-7977331-B1 | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor | JAPAN TOBACCO INC. (JP) | 2011-07-12 | — | — | US | disclosed |
| EP-2206715-A1 | Fused heterotetracyclic compounds and use thereof as hcv polymerase inhibitor | Japan Tobacco, Inc. (JP) | 2010-07-14 | — | — | EP | disclosed |