Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 2/20 | 0.37 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.36 |
| ▸ | P2RX2 | Q9UBL9 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 8/20 | 0.34 |
| ▸ | PRKCA | P17252 | 1/20 | 0.34 |
| ▸ | MMP12 | P39900 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL804990 | 0.93 | PRKCA (0.40) | SCN9AKCNH2NR1I2PRKCAMMP12 | |
| SCHEMBL12428691 | 0.86 | SCN9A (0.39) | SCN9AKCNH2NR1I2PRKCAMMP12 | |
| SCHEMBL14606871 | 0.83 | SCN9A (0.36) | SCN9AKCNH2NR1I2PRKCAMMP12 | |
| SCHEMBL14572872 | 0.83 | SCN9A (0.34) | SCN9AKCNH2NR1I2PRKCAMMP12 | |
| SCHEMBL12429333 | 0.83 | SCN9A (0.42) | SCN9AKCNH2NR1I2PRKCAMMP12 | |
| SCHEMBL10283283 | 0.81 | PRKCA (0.40) | SCN9AKCNH2NR1I2PRKCAMMP12 | |
| SCHEMBL12428079 | 0.81 | PRKCA (0.40) | SCN9AKCNH2NR1I2PRKCAMMP12 | |
| SCHEMBL803712 | 0.81 | PRKCA (0.40) | SCN9AKCNH2NR1I2PRKCAMMP12 | |
| SCHEMBL792670 | 0.81 | KMT2A (0.34) | SCN9ANR1I2 | |
| SCHEMBL10283565 | 0.80 | CHRM2 (0.45) | SCN9ANR1I2PRKCAMMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7977331-B1 | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor | JAPAN TOBACCO INC. (JP) | 2011-07-12 | — | — | US | disclosed |
| US-7977331-B1 | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor | JAPAN TOBACCO INC. (JP) | 2011-07-12 | — | — | US | disclosed |