Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 1/20 | 0.46 |
| ▸ | MMP12 | P39900 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.44 |
| ▸ | NR1I2 | O75469 | 5/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.39 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.36 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.36 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12428868 | 0.91 | KCNH2 (0.45) | PRKCAMMP12KCNH2CYP3A4SCN5A | |
| SCHEMBL12428862 | 0.91 | PRKCA (0.44) | PRKCAMMP12KCNH2CYP3A4SCN5A | |
| SCHEMBL12427623 | 0.90 | PRKCA (0.43) | PRKCAMMP12KCNH2CYP3A4SCN5A | |
| SCHEMBL12427570 | 0.89 | PRKCA (0.46) | PRKCAMMP12KCNH2CYP3A4SCN5A | |
| SCHEMBL12427609 | 0.89 | PRKCA (0.43) | PRKCAMMP12KCNH2CYP3A4SCN5A | |
| SCHEMBL12427611 | 0.89 | KCNH2 (0.42) | PRKCAMMP12KCNH2CYP3A4SCN5A | |
| SCHEMBL12429418 | 0.88 | KCNH2 (0.44) | PRKCAMMP12KCNH2CYP3A4SCN5A | |
| SCHEMBL12427612 | 0.88 | PRKCA (0.44) | PRKCAMMP12KCNH2CYP3A4SCN5A | |
| SCHEMBL12428863 | 0.88 | PRKCA (0.45) | PRKCAMMP12KCNH2CYP3A4SCN5A | |
| SCHEMBL12429364 | 0.87 | PRKCA (0.42) | PRKCAMMP12KCNH2CYP3A4SCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7977331-B1 | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor | JAPAN TOBACCO INC. (JP) | 2011-07-12 | — | — | US | disclosed |
| US-7977331-B1 | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor | JAPAN TOBACCO INC. (JP) | 2011-07-12 | — | — | US | disclosed |