SCHEMBL12428892

SCHEMBL12428892

CCN(CCN1CCOCC1)c1cccc2c1OCCn1c-2c(C2CCCCC2)c2ccc(C(=O)O)cc21

nearest known ligand 0.49

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
PRKCA P17252 1/20 0.49
MMP12 P39900 1/20 0.49
NR1I2 O75469 1/20 0.41
SCN9A Q15858 3/20 0.38
CASR P41180 5/20 0.37
NTSR1 P30989 1/20 0.35
MEN1 O00255 1/20 0.34
KMT2A Q03164 1/20 0.34
PTGER4 P35408 1/20 0.33
EPHX2 P34913 2/20 0.33
BRD4 O60885 1/20 0.32
CNR1 P21554 2/20 0.32
CNR2 P34972 2/20 0.32
HTR2A P28223 1/20 0.32
HTR7 P34969 1/20 0.32
KCNH2 Q12809 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL771848 0.99 PRKCA (0.48) PRKCAMMP12NR1I2SCN9ACASR
SCHEMBL10283211 0.98 PRKCA (0.47) PRKCAMMP12NR1I2SCN9ACASR
Hydrochloric Acid SCHEMBL772635 0.97 PRKCA (0.47) PRKCAMMP12NR1I2SCN9ACASR
SCHEMBL803866 0.95 PRKCA (0.50) PRKCAMMP12NR1I2SCN9ACASR
SCHEMBL12429508 0.95 PRKCA (0.50) PRKCAMMP12NR1I2SCN9ACASR
SCHEMBL12429072 0.95 PRKCA (0.49) PRKCAMMP12NR1I2SCN9ACASR
Hydrochloric Acid SCHEMBL772764 0.95 PRKCA (0.49) PRKCAMMP12NR1I2SCN9ACASR
Hydrochloric Acid SCHEMBL772877 0.95 PRKCA (0.49) PRKCAMMP12NR1I2SCN9ACASR
Hydrochloric Acid SCHEMBL771275 0.95 PRKCA (0.49) PRKCAMMP12NR1I2SCN9ACASR
SCHEMBL12429069 0.93 PRKCA (0.48) PRKCAMMP12NR1I2SCN9ACASR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7977331-B1 Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor JAPAN TOBACCO INC. (JP) 2011-07-12 US disclosed
US-7977331-B1 Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor JAPAN TOBACCO INC. (JP) 2011-07-12 US disclosed