Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.31 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.31 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.30 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14206417 | 0.88 | KDR (0.33) | KDRADORA3MEN1USP2POLB | |
| SCHEMBL2076345 | 0.88 | KDR (0.36) | KDRADORA3 | |
| SCHEMBL12427883 | 0.88 | KDR (0.33) | KDRADORA3 | |
| SCHEMBL2076372 | 0.81 | BCDIN3D (0.33) | KDRADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL2076725 | 0.80 | CNR1 (0.32) | KDRADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL2078684 | 0.80 | KDR (0.36) | KDR | |
| SCHEMBL2077564 | 0.78 | AURKA (0.33) | KDR | |
| SCHEMBL2078312 | 0.78 | TLR8 (0.35) | KDRADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL2075216 | 0.77 | LRRK2 (0.33) | KDR | |
| SCHEMBL12428993 | 0.76 | USP2 (0.37) | ADORA3USP2POLBMAPTADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2351751-A1 | Substituted pyrazolopyrimidines | CEPHALON, INC. (US) | 2011-08-03 | — | — | EP | disclosed |