Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 1/20 | 0.47 |
| ▸ | MMP12 | P39900 | 1/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 6/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KMO | O15229 | 1/20 | 0.35 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.34 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL774479 | 0.99 | PRKCA (0.47) | PRKCAMMP12SCN9ACYP3A4CYP2C19 | |
| SCHEMBL773877 | 0.93 | PRKCA (0.52) | PRKCAMMP12SCN9ANR1I2POLB | |
| SCHEMBL804237 | 0.91 | PRKCA (0.46) | PRKCAMMP12SCN9ANR1I2HPGD | |
| Hydrochloric Acid SCHEMBL771873 | 0.91 | PRKCA (0.46) | PRKCAMMP12SCN9ANR1I2HPGD | |
| SCHEMBL774666 | 0.87 | PRKCA (0.48) | PRKCAMMP12SCN9ANR1I2KMO | |
| SCHEMBL774624 | 0.85 | PRKCA (0.50) | PRKCAMMP12SCN9ACYP3A4NR1I2 | |
| SCHEMBL771845 | 0.85 | PRKCA (0.51) | PRKCAMMP12SCN9ACYP3A4CYP2C19 | |
| SCHEMBL772514 | 0.84 | PRKCA (0.49) | PRKCAMMP12SCN9ANR1I2HPGD | |
| SCHEMBL773242 | 0.84 | PRKCA (0.55) | PRKCAMMP12SCN9ACYP3A4CYP2C19 | |
| SCHEMBL773902 | 0.83 | PRKCA (0.50) | PRKCAMMP12SCN9ANR1I2KMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7977331-B1 | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor | JAPAN TOBACCO INC. (JP) | 2011-07-12 | — | — | US | disclosed |
| US-7977331-B1 | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor | JAPAN TOBACCO INC. (JP) | 2011-07-12 | — | — | US | disclosed |