Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 1/20 | 0.48 |
| ▸ | MMP12 | P39900 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | NR1I2 | O75469 | 5/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 2/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12427922 | 0.91 | PRKCA (0.51) | PRKCAMMP12CYP3A4CYP2C19CYP2C9 | |
| SCHEMBL792699 | 0.91 | PRKCA (0.41) | PRKCAMMP12CYP3A4CYP2C19CYP2C9 | |
| SCHEMBL12429409 | 0.90 | PRKCA (0.46) | PRKCAMMP12CYP3A4CYP2C19CYP2C9 | |
| SCHEMBL12429287 | 0.89 | PRKCA (0.46) | PRKCAMMP12CYP3A4CYP2C19CYP2C9 | |
| SCHEMBL12429404 | 0.89 | PRKCA (0.48) | PRKCAMMP12CYP3A4CYP2C19CYP2C9 | |
| SCHEMBL12429243 | 0.89 | PRKCA (0.51) | PRKCAMMP12CYP3A4CYP2C19CYP2C9 | |
| SCHEMBL12428350 | 0.88 | PRKCA (0.46) | PRKCAMMP12CYP3A4CYP2C19CYP2C9 | |
| SCHEMBL12428084 | 0.88 | PRKCA (0.52) | PRKCAMMP12CYP3A4CYP2C19CYP2C9 | |
| SCHEMBL12429424 | 0.87 | PRKCA (0.46) | PRKCAMMP12CYP3A4CYP2C19CYP2C9 | |
| SCHEMBL12429405 | 0.86 | PRKCA (0.46) | PRKCAMMP12CYP3A4CYP2C19CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7977331-B1 | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor | JAPAN TOBACCO INC. (JP) | 2011-07-12 | — | — | US | disclosed |
| US-7977331-B1 | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor | JAPAN TOBACCO INC. (JP) | 2011-07-12 | — | — | US | disclosed |