Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.37 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2266880 | 0.84 | POLB (0.50) | POLBMAPTKDM4EHPGDALDH1A1 | |
| SCHEMBL7991998 | 0.84 | KDM4E (0.55) | POLBMAPTKDM4EHPGDALDH1A1 | |
| Bromide SCHEMBL11354067 | 0.82 | POLB (0.49) | POLBMAPTKDM4EHPGDALDH1A1 | |
| SCHEMBL12819467 | 0.81 | MAPT (0.51) | POLBMAPTKDM4EHPGDALDH1A1 | |
| SCHEMBL30390720 | 0.79 | MAPT (0.50) | POLBMAPTKDM4EHPGDALDH1A1 | |
| SCHEMBL10268918 | 0.79 | MAPT (0.50) | POLBMAPTKDM4EHPGDALDH1A1 | |
| SCHEMBL2947016 | 0.78 | ALDH1A1 (0.53) | POLBMAPTKDM4EHPGDALDH1A1 | |
| SCHEMBL855939 | 0.78 | MAPT (0.49) | POLBMAPTKDM4EHPGDALDH1A1 | |
| SCHEMBL8531612 | 0.78 | MAPT (0.49) | POLBMAPTKDM4EHPGDALDH1A1 | |
| SCHEMBL13041691 | 0.77 | ALDH1A1 (0.59) | POLBMAPTKDM4EHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888579-B1 | NOVEL FLUORENE DERIVATIVES, COMPOSITION CONTAINING SAID DERIVATIVES AND THE USE THEREOF | AVENTIS PHARMA SA (FR) | 2011-08-03 | — | — | EP | disclosed |