Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 5/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | FLT1 | P17948 | 1/20 | 0.36 |
| ▸ | CASP6 | P55212 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12431593 | 0.82 | HSP90AB1 (0.85) | HSP90AB1KDM4EALDH1A1HPGDNPC1 | |
| SCHEMBL13437174 | 0.82 | HSP90AB1 (0.68) | HSP90AB1KDM4EALDH1A1HPGDNPC1 | |
| SCHEMBL13437184 | 0.79 | HSP90AB1 (0.77) | HSP90AB1KDM4EALDH1A1HPGDNPC1 | |
| SCHEMBL12430602 | 0.78 | HSP90AB1 (0.52) | HSP90AB1KDM4EALDH1A1HPGDNPC1 | |
| SCHEMBL21477061 | 0.78 | HSP90AB1 (0.58) | HSP90AB1KDM4EALDH1A1HPGDNPC1 | |
| SCHEMBL13437146 | 0.77 | HSP90AB1 (0.47) | HSP90AB1KDM4EALDH1A1HPGDNPC1 | |
| SCHEMBL12430419 | 0.77 | HSP90AB1 (0.47) | HSP90AB1KDM4EALDH1A1HPGDNPC1 | |
| SCHEMBL12431588 | 0.76 | HSP90AB1 (0.57) | HSP90AB1KDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL13437143 | 0.75 | HSP90AB1 (0.85) | HSP90AB1KDM4EALDH1A1HPGDNPC1 | |
| SCHEMBL27263584 | 0.75 | HSP90AB1 (0.53) | HSP90AB1KDM4EALDH1A1HPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888579-B1 | NOVEL FLUORENE DERIVATIVES, COMPOSITION CONTAINING SAID DERIVATIVES AND THE USE THEREOF | AVENTIS PHARMA SA (FR) | 2011-08-03 | — | — | EP | disclosed |