Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 7/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | HTR7 | P34969 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12150976 | 0.90 | HDAC1 (0.77) | HDAC1MAPTLMNANPSR1GAA | |
| SCHEMBL12432013 | 0.88 | MAPT (0.76) | HDAC1MAPTLMNANPSR1ALDH1A1 | |
| SCHEMBL14032587 | 0.86 | CNR1 (0.59) | HDAC1MAPTLMNANPSR1GAA | |
| SCHEMBL12432008 | 0.84 | MAPT (0.64) | HDAC1MAPTLMNANPSR1HTT | |
| SCHEMBL27857404 | 0.83 | MAPT (0.64) | HDAC1MAPTLMNANPSR1GAA | |
| SCHEMBL10977202 | 0.81 | MAPT (0.61) | HDAC1MAPTLMNANPSR1GAA | |
| SCHEMBL12431958 | 0.80 | ALDH1A1 (0.68) | HDAC1MAPTLMNANPSR1ALDH1A1 | |
| SCHEMBL12432012 | 0.80 | ALDH1A1 (0.68) | HDAC1MAPTLMNANPSR1ALDH1A1 | |
| SCHEMBL12047642 | 0.77 | MAPT (0.61) | MAPTLMNANPSR1GAAHTT | |
| SCHEMBL22542017 | 0.77 | HTT (0.57) | MAPTLMNAGAAHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7981895-B2 | Histone deacetylase inhibitor; anticancer agents; antiproliferative agents; antitumor agents; psoriasis; piperazine compound containing a carbamic acid group | TOPOTARGET UK LIMITED (GB) | 2011-07-19 | — | — | US | disclosed |