Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 10/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 10/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 8/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.39 |
| ▸ | TAS1R3 | Q7RTX0 | 3/20 | 0.38 |
| ▸ | TAS1R1 | Q7RTX1 | 3/20 | 0.38 |
| ▸ | NCOR2 | Q9Y618 | 4/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29922632 | 0.82 | HDAC3 (0.40) | HDAC3HDAC1HDAC2HDAC8HDAC4 | |
| SCHEMBL21799890 | 0.82 | HDAC3 (0.40) | HDAC3HDAC1HDAC2HDAC8HDAC4 | |
| SCHEMBL20685224 | 0.80 | KCNH2 (0.42) | HDAC3HDAC1HDAC2HDAC8HDAC4 | |
| SCHEMBL11415357 | 0.75 | IDO1 (0.49) | HDAC3HDAC1HDAC2HDAC8HDAC4 | |
| SCHEMBL29922607 | 0.74 | TLR8 (0.41) | HDAC3HDAC1HDAC2HDAC8HDAC4 | |
| SCHEMBL21799545 | 0.74 | TLR8 (0.41) | HDAC3HDAC1HDAC2HDAC8HDAC4 | |
| SCHEMBL2312159 | 0.73 | ALDH1A1 (0.42) | HDAC3HDAC1HDAC2HDAC8HDAC4 | |
| SCHEMBL2312151 | 0.73 | ALDH1A1 (0.42) | HDAC3HDAC1HDAC2HDAC8HDAC4 | |
| SCHEMBL21799625 | 0.68 | IDO1 (0.42) | HDAC3HDAC1HDAC2HDAC8HDAC4 | |
| SCHEMBL22692976 | 0.67 | CYP1A2 (0.39) | HDAC3HDAC1HDAC2HDAC8HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2152674-B1 | BENZIMIDAZOLONE CHYMASE INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2011-08-03 | — | — | EP | disclosed |