Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL580818 | 0.86 | TTR (0.55) | NOTUMSMN1; SMN2TP53MAPTTHRB | |
| SCHEMBL23648381 | 0.82 | SMN1; SMN2 (0.54) | NOTUMSMN1; SMN2TP53MAPTTHRB | |
| SCHEMBL250807 | 0.82 | SMN1; SMN2 (0.59) | NOTUMSMN1; SMN2TP53MAPTTHRB | |
| SCHEMBL2709426 | 0.82 | SMN1; SMN2 (0.56) | NOTUMSMN1; SMN2TP53MAPTTHRB | |
| SCHEMBL1962242 | 0.80 | TP53 (0.49) | NOTUMSMN1; SMN2TP53MAPTTHRB | |
| SCHEMBL20716309 | 0.80 | NPC1 (0.52) | NOTUMSMN1; SMN2TP53MAPTTHRB | |
| SCHEMBL1962239 | 0.80 | NOTUM (0.50) | NOTUMSMN1; SMN2TP53MAPTTHRB | |
| SCHEMBL1962241 | 0.80 | NOTUM (0.50) | NOTUMSMN1; SMN2TP53MAPTTHRB | |
| SCHEMBL20703196 | 0.79 | NPC1 (0.55) | NOTUMSMN1; SMN2TP53MAPTTHRB | |
| SCHEMBL249879 | 0.79 | NOTUM (0.58) | NOTUMSMN1; SMN2TP53MAPTTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011093684-A2 | THIENO[3,2-d]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY ON PROTEIN KINASES | HANMI HOLDINGS CO., LTD. (KR) | 2011-08-04 | — | — | WO | disclosed |