Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.44 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
| ▸ | PRKDC | P78527 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL249224 | 0.83 | NOTUM (0.50) | NOTUMALDH1A1PDE3BPDE3AS1PR1 | |
| SCHEMBL17102319 | 0.81 | NOTUM (0.54) | NOTUMALDH1A1KDM4ELMNAPDE3B | |
| SCHEMBL1929073 | 0.81 | MAPT (0.61) | NOTUMALDH1A1KDM4ELMNAPDE3B | |
| SCHEMBL7911412 | 0.81 | NOTUM (0.54) | NOTUMALDH1A1KDM4ELMNAPDE3B | |
| SCHEMBL31210319 | 0.81 | MAPT (0.61) | NOTUMALDH1A1KDM4ELMNAPDE3B | |
| SCHEMBL24680705 | 0.81 | NOTUM (0.54) | NOTUMALDH1A1KDM4ELMNAPDE3B | |
| SCHEMBL29623590 | 0.81 | NOTUM (0.54) | NOTUMALDH1A1KDM4ELMNAPDE3B | |
| SCHEMBL12433016 | 0.79 | NOTUM (0.53) | NOTUMALDH1A1KDM4ELMNAPDE3B | |
| SCHEMBL12139639 | 0.78 | ALDH1A1 (0.56) | NOTUMALDH1A1KDM4ELMNAPDE3B | |
| SCHEMBL10232907 | 0.77 | NOTUM (0.51) | NOTUMALDH1A1KDM4ELMNAPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401275-A1 | NOVEL BRONCHODILATING DIAZAHETEROARYLS | Respiratorius AB (SE) | 2012-01-04 | — | — | EP | claimed |