Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 6/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | KCNMA1 | Q12791 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7916871 | 0.85 | KDM4E (0.50) | GAAMEN1KMT2AMAPTAAK1 | |
| SCHEMBL12432823 | 0.85 | HRH2 (0.42) | GAAMAPTAAK1KDM4EGLA | |
| SCHEMBL2031546 | 0.85 | KCNMA1 (0.54) | GAAMAPTSMN1; SMN2KCNMA1NPC1 | |
| SCHEMBL1390928 | 0.84 | KDM4E (0.48) | GAAMEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL1390927 | 0.84 | KDM4E (0.48) | GAAMEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL13497782 | 0.83 | CYP1A2 (0.46) | GAAMEN1KMT2ATHRBMAPT | |
| SCHEMBL15020425 | 0.83 | HPGD (0.51) | GAAMEN1KMT2AMAPTNPC1 | |
| SCHEMBL12432821 | 0.81 | GAA (0.56) | GAAMEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL8071230 | 0.81 | MEN1 (0.43) | GAAMEN1KMT2ATHRBMAPT | |
| SCHEMBL12432828 | 0.78 | HRH2 (0.42) | GAAMEN1KMT2AMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2351743-A1 | BICYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2011-08-03 | — | — | EP | disclosed |