SCHEMBL12433522

SCHEMBL12433522

N#Cc1c(Cl)cccc1Oc1ccc(-c2ccc(Oc3cccc(Oc4ccc(C(c5ccc(Oc6cccc(Cl)c6C#N)cc5)(C(F)(F)F)C(F)(F)F)cc4)c3C#N)cc2)cc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TLR8 Q9NR97 4/20 0.53
MAPT P10636 1/20 0.46
HSD11B1 P28845 1/20 0.43
BCL2L1 Q07817 1/20 0.42
MCL1 Q07820 1/20 0.42
AR P10275 3/20 0.41
KDM4E B2RXH2 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
MEN1 O00255 1/20 0.34
CNR1 P21554 1/20 0.34
GPR183 P32249 1/20 0.34
CNR2 P34972 1/20 0.34
KMT2A Q03164 1/20 0.34
CASR P41180 3/20 0.33
SCN9A Q15858 2/20 0.33
ADRB2 P07550 1/20 0.33
CYP2D6 P10635 1/20 0.33
SLC6A2 P23975 1/20 0.33
SLC6A4 P31645 1/20 0.33
SLC6A3 Q01959 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10084200 0.95 TLR8 (0.51) TLR8MAPTHSD11B1BCL2L1MCL1
SCHEMBL2628127 0.88 TLR8 (0.44) TLR8MAPTHSD11B1BCL2L1MCL1
SCHEMBL16199841 0.86 MAPT (0.46) TLR8MAPTHSD11B1BCL2L1MCL1
SCHEMBL14827176 0.85 AR (0.43) TLR8MAPTHSD11B1BCL2L1MCL1
SCHEMBL12780756 0.85 TLR8 (0.67) TLR8MAPTHSD11B1BCL2L1MCL1
SCHEMBL14264194 0.85 TLR8 (0.55) TLR8MAPTHSD11B1BCL2L1MCL1
SCHEMBL14827185 0.84 AR (0.44) TLR8MAPTHSD11B1BCL2L1MCL1
SCHEMBL12433519 0.83 MAPT (0.41) TLR8MAPTHSD11B1BCL2L1MCL1
SCHEMBL14827188 0.83 AR (0.43) TLR8MAPTHSD11B1BCL2L1MCL1
SCHEMBL13910270 0.82 POLB (0.43) TLR8MAPTARKDM4EMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7981566-B2 Membrane electrode assembly and polymer electrolyte fuel cell therewith HONDA MOTOR CO., LTD. (JP) 2011-07-19 US disclosed
US-20100190088-A1 MEMBRANE ELECTRODE ASSEMBLY AND POLYMER ELECTROLYTE FUEL CELL THEREWITH HONDA MOTOR CO., LTD. (JP) 2010-07-29 US disclosed
US-7727652-B2 Membrane electrode assembly and polymer electrolyte fuel cell therewith HONDA MOTOR CO., LTD. (JP) 2010-06-01 US disclosed
US-20080070085-A1 Sulfonated Polymer Comprising Nitrile-Type Hydrophobic Block And Solid Polymer Electrolyte HONDA MOTOR CO., LTD. (JP) 2008-03-20 US disclosed