SCHEMBL12433519

SCHEMBL12433519

N#Cc1c(Cl)cccc1Oc1ccc(C2(c3ccc(Oc4cccc(Oc5ccc(C(c6ccc(Oc7cccc(Cl)c7C#N)cc6)(C(F)(F)F)C(F)(F)F)cc5)c4C#N)cc3)c3ccccc3-c3ccccc32)cc1

nearest known ligand 0.41

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.41
TLR8 Q9NR97 1/20 0.40
HSD11B1 P28845 1/20 0.39
AR P10275 2/20 0.36
BCL2L1 Q07817 1/20 0.33
MCL1 Q07820 1/20 0.33
PDK2 Q15119 1/20 0.32
KDM4E B2RXH2 1/20 0.31
MEN1 O00255 1/20 0.31
LMNA P02545 1/20 0.31
OPRK1 P41145 1/20 0.31
KMT2A Q03164 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
CASR P41180 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15760417 0.89 AR (0.37) MAPTHSD11B1ARPDK2KDM4E
SCHEMBL12433514 0.88 MAPT (0.50) MAPTTLR8HSD11B1ARBCL2L1
SCHEMBL14264198 0.88 MAPT (0.43) MAPTTLR8HSD11B1ARBCL2L1
SCHEMBL13250812 0.88 MAPT (0.43) MAPTTLR8HSD11B1ARBCL2L1
SCHEMBL17808971 0.85 AR (0.37) MAPTARPDK2SMN1; SMN2
SCHEMBL10084200 0.85 TLR8 (0.51) MAPTTLR8HSD11B1ARBCL2L1
SCHEMBL13250809 0.84 MAPT (0.40) MAPTTLR8HSD11B1ARBCL2L1
SCHEMBL13250811 0.84 MAPT (0.45) MAPTTLR8HSD11B1ARBCL2L1
SCHEMBL12433522 0.83 TLR8 (0.53) MAPTTLR8HSD11B1ARBCL2L1
SCHEMBL2628128 0.82 MAPT (0.43) MAPTTLR8HSD11B1ARBCL2L1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7981566-B2 Membrane electrode assembly and polymer electrolyte fuel cell therewith HONDA MOTOR CO., LTD. (JP) 2011-07-19 US disclosed
US-20100190088-A1 MEMBRANE ELECTRODE ASSEMBLY AND POLYMER ELECTROLYTE FUEL CELL THEREWITH HONDA MOTOR CO., LTD. (JP) 2010-07-29 US disclosed
US-7727652-B2 Membrane electrode assembly and polymer electrolyte fuel cell therewith HONDA MOTOR CO., LTD. (JP) 2010-06-01 US disclosed
US-20080070085-A1 Sulfonated Polymer Comprising Nitrile-Type Hydrophobic Block And Solid Polymer Electrolyte HONDA MOTOR CO., LTD. (JP) 2008-03-20 US disclosed