Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.42 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12436008 | 0.90 | SMN1; SMN2 (0.56) | SMN1; SMN2NPSR1HTTLMNAALDH1A1 | |
| SCHEMBL12436015 | 0.89 | LMNA (0.62) | SMN1; SMN2NPSR1HTTLMNAALDH1A1 | |
| SCHEMBL2218687 | 0.89 | SMN1; SMN2 (0.59) | SMN1; SMN2NPSR1HTTLMNAALDH1A1 | |
| SCHEMBL12436017 | 0.87 | SMN1; SMN2 (0.63) | SMN1; SMN2NPSR1HTTLMNAALDH1A1 | |
| SCHEMBL12435992 | 0.83 | SMN1; SMN2 (0.45) | SMN1; SMN2NPSR1HTTLMNAALDH1A1 | |
| SCHEMBL12436012 | 0.81 | LMNA (0.50) | SMN1; SMN2NPSR1HTTLMNAALDH1A1 | |
| SCHEMBL2219490 | 0.80 | SMN1; SMN2 (0.59) | SMN1; SMN2NPSR1HTTLMNAALDH1A1 | |
| SCHEMBL12436006 | 0.80 | HTT (0.49) | SMN1; SMN2HTTLMNAKMT2AMEN1 | |
| SCHEMBL12435909 | 0.79 | ATM (0.52) | SMN1; SMN2HTTLMNAALDH1A1KMT2A | |
| SCHEMBL12435995 | 0.78 | HTT (0.42) | SMN1; SMN2NPSR1HTTLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110178108-A1 | Group of amino substituted benzoyl derivatives and their preparation and their use | Institute of Medicinal Biotechnology Academy of Medical Science (CN) | 2011-07-21 | — | — | US | disclosed |
| US-20110178108-A1 | Group of amino substituted benzoyl derivatives and their preparation and their use | Institute of Medicinal Biotechnology Academy of Medical Science (CN) | 2011-07-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110178108-A1 | Group of amino substituted benzoyl derivatives and their preparation and their use | CUL3, APOBEC3G, BRPF3 | SMN1; SMN2 4598/4885NPSR1 4225/4885HTT 1248/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.