Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 4/20 | 0.59 |
| ▸ | THRB | P10828 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.53 |
| ▸ | DRD4 | P21917 | 2/20 | 0.52 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.52 |
| ▸ | SLC6A13 | Q9NSD5 | 1/20 | 0.52 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12437758 | 0.94 | UTS2R (0.53) | TP53THRBSMN1; SMN2MCHR1DRD4 | |
| SCHEMBL12437747 | 0.89 | UTS2R (0.60) | TP53THRBSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL12437736 | 0.84 | UTS2R (0.61) | TP53THRBKMT2AMEN1MCHR1 | |
| SCHEMBL12437880 | 0.83 | TP53 (0.49) | TP53THRBSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL13158246 | 0.82 | TP53 (0.54) | TP53THRBSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL12437754 | 0.82 | UTS2R (0.62) | KMT2AMEN1DRD4 | |
| SCHEMBL12437769 | 0.82 | HRH3 (0.47) | TP53THRBSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL12437888 | 0.81 | TP53 (0.47) | TP53THRBSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL12437730 | 0.81 | TP53 (0.47) | TP53THRBSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL13158788 | 0.80 | TP53 (0.53) | TP53THRBSMN1; SMN2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110178066-A1 | Hydroxypiperidine derivatives and uses thereof | AVALON PHARMACEUTICALS | 2011-07-21 | — | — | US | disclosed |
| US-20110178066-A1 | Hydroxypiperidine derivatives and uses thereof | AVALON PHARMACEUTICALS | 2011-07-21 | — | — | US | disclosed |
| US-20090036429-A1 | Hydroxypiperidine Derivatives and Uses Thereof | AVALON PHARMACEUTICALS | 2009-02-05 | — | — | US | disclosed |
| US-20090036429-A1 | Hydroxypiperidine Derivatives and Uses Thereof | AVALON PHARMACEUTICALS | 2009-02-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110178066-A1 | Hydroxypiperidine derivatives and uses thereof | HPGDS, HPGD, DPYD | TP53 7/4885THRB 3280/4885SMN1; SMN2 4539/4885 |
| US-20090036429-A1 | Hydroxypiperidine Derivatives and Uses Thereof | HPGDS, HPGD, DPYD | TP53 7/4885THRB 3280/4885SMN1; SMN2 4539/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.