HPGDS — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL27589	1.00	20/20
SCHEMBL27787	1.00	20/20
SCHEMBL29363	1.00	20/20
SCHEMBL28492	0.81	20/20
SCHEMBL28039	1.00	19/20
SCHEMBL28315	1.00	19/20
SCHEMBL28514	1.00	19/20
SCHEMBL28944	1.00	19/20
SCHEMBL28314	0.73	19/20
SCHEMBL27313	1.00	18/20
SCHEMBL27841	1.00	18/20
SCHEMBL28180	1.00	18/20
SCHEMBL28360	1.00	18/20
SCHEMBL28504	0.92	18/20
SCHEMBL28861	0.71	18/20
SCHEMBL28221	0.69	18/20
SCHEMBL28222	1.00	17/20
SCHEMBL28755	1.00	17/20
Morpholine (SCHEMBL28316)	0.59	17/20
SCHEMBL38259	1.00	16/20

Clinical trials — most relevant to HPGDS by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Type 2 Diabetes Mellitus and Atherosclerosis	PHASE4	UNKNOWN
Atorvastatin, Aspirin, Oxidative Stress, Coagulation and Platelet Activation Indexes	PHASE4	UNKNOWN
A Clinical Trial to Study the Effects of Two Drugs, Lycopene and Prednisolone in Patients With Oral Lichen Planus	PHASE4	COMPLETED
Topical Cetirizine 1% vs Minoxidil 5% Gel in Treatment of Androgenetic Alopecia	PHASE4	UNKNOWN
European Celecoxib Trial in Primary Breast Cancer	PHASE3	COMPLETED
Aspirin and Renal Disease Progression in Patients With Type 2 Diabetes	PHASE3	UNKNOWN
Addition of Aspirin to Standard of Care in Oral Cancer	PHASE2/PHASE3	COMPLETED
Selective COX-II Inhibitor as a Palliative Therapy in Patients With R1 or R2 Resection for Disseminated Stomach Cancer - A Multi-Centre Prospective Randomized Controlled Trial	PHASE3	UNKNOWN
Ramatroban/Montelukast Versus Montelukast/Placebo on the Early Allergic Reaction in Asthma Sensitive to House Dust Mite	PHASE2/PHASE3	WITHDRAWN
Changes in Breast Cancer Biomarkers Using Synergistic Prostaglandin Inhibitors	PHASE1/PHASE2	COMPLETED
Comparision Between Paracetamol and Ibuprofen in Closure of Patent Ductus Arteriosus	PHASE2	UNKNOWN
Immunomodulating Therapy and Improved Vaccination Responses by Cox-2 Inhibitor in HIV-infected Patients	PHASE2	COMPLETED
Prostaglandin Inhibition for Emphysema	PHASE2	COMPLETED
Changes in Biomarkers Using Prostaglandin Inhibitors	PHASE1/PHASE2	COMPLETED
Trial of Zileuton CR in Children and Adults With Sickle Cell Disease	PHASE1	COMPLETED
Lipidomics Screening of Celecoxib in ex Vivo Human Whole Blood Assay - Part B	nan	COMPLETED
Lipidomics Screening of Anti-inflammatory Drugs and Drug Candidates in Vitro - Part A	nan	ACTIVE_NOT_RECRUITING
Study About Patients Using Copper Intrauterine Device	nan	COMPLETED
Urinary PGE-MUM (PROSTAGLANDIN E-MAJOR URINARY METABOLITE) as Inflammatory Marker in Chronic Inflammatory Bowel Disease	nan	COMPLETED
Maresin-1 and Resolvin-D1 Levels and Disease Activity in Ulcerative Colitis	nan	COMPLETED
EPICO: (Study for the Pro-resolution of Chronic Inflammation in Obesity. Original Acronym From Spanish)	nan	UNKNOWN
Peri-implantitis and MMP-8	nan	COMPLETED
Association and Mechanism Between Cyclooxygenase-2 and Interleukin-6 in Gastric Cancer	nan	UNKNOWN
The Role of Lymphangiogenesis in Head and Neck Cancer Metastasis	nan	UNKNOWN
The Neuroprotective Effect of Dexmedetomidine Preserving Brain Functional Connectivity in Elderly Patients	nan	COMPLETED
Eicosanoid Lipids by Airway Cells During Infection With Human Rhinoviruses	nan	COMPLETED
Investigation of Lipoxin A4, Annexin A1 and Interleukin-1 Beta Levels in Individuals With Periodontitis.	nan	COMPLETED
Mild Intermittent Hypoxia and Its Multipronged Effect on Sleep Apnea	nan	RECRUITING
Impact of Vitamin D Supplementation on Hepcidin Levels and Transfusion Requirements in Surgical and Septic Patients	nan	UNKNOWN
Reactive Oxygen Species in the Pathogenesis of Diabetic Complications	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a HPGDS binder may also engage these)

Protein	Name	Similarity
O35543	—	0.996	O35543 →
Q9JHF7	—	0.996	Q9JHF7 →
P91252	—	0.993	P91252 →
P30114	—	0.990	P30114 →
Q09607	—	0.990	Q09607 →
Q08862	—	0.990	Q08862 →
Q21743	—	0.990	Q21743 →
P26624	—	0.989	P26624 →
P18426	—	0.989	P18426 →
P10299	—	0.988	P10299 →
P09792	—	0.988	P09792 →
Q21355	—	0.988	Q21355 →
O73888	—	0.987	O73888 →
P30113	—	0.987	P30113 →
Q08393	—	0.987	Q08393 →
O16116	—	0.987	O16116 →
O16115	—	0.987	O16115 →
Q9N4X8	—	0.986	Q9N4X8 →
Q54QV7	—	0.986	Q54QV7 →
P46419	—	0.986	P46419 →
P26697	—	0.985	P26697 →
Q7RTV2	—	0.985	Q7RTV2 →
P30115	—	0.985	P30115 →
Q08863	—	0.985	Q08863 →
GSTA1	Glutathione S-transferase A1	0.985	landscape →
P46427	—	0.985	P46427 →
P46426	—	0.985	P46426 →
Q5E9G0	—	0.985	Q5E9G0 →
P46088	—	0.984	P46088 →
Q08392	—	0.984	Q08392 →