Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 12/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 2/20 | 0.37 |
| ▸ | FLT3 | P36888 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14050427 | 0.84 | IGF1R (0.51) | IGF1R | |
| SCHEMBL12438114 | 0.83 | IGF1R (0.48) | IGF1R | |
| SCHEMBL4458407 | 0.76 | IGF1R (0.80) | IGF1R | |
| SCHEMBL14050353 | 0.75 | IGF1R (0.45) | IGF1R | |
| SCHEMBL12439839 | 0.75 | IGF1R (0.53) | IGF1RLCKKITFLT3 | |
| SCHEMBL15721540 | 0.75 | IGF1R (0.52) | IGF1RLCK | |
| SCHEMBL14050611 | 0.75 | IGF1R (0.46) | IGF1R | |
| SCHEMBL12438527 | 0.74 | IGF1R (0.64) | IGF1R | |
| SCHEMBL12439860 | 0.73 | IGF1R (0.47) | IGF1R | |
| SCHEMBL12439851 | 0.71 | IGF1R (0.62) | IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1841760-B1 | PYRIMIDINE DERIVATIVES AS KINASE MODULATORS AND METHOD OF USE | EXELIXIS INC (US) | 2011-08-10 | — | — | EP | disclosed |