Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 17/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12438267 | 0.87 | IGF1R (0.46) | IGF1R | |
| SCHEMBL12438114 | 0.83 | IGF1R (0.48) | IGF1R | |
| SCHEMBL12438590 | 0.82 | IGF1R (0.43) | IGF1R | |
| SCHEMBL14050427 | 0.81 | IGF1R (0.51) | IGF1R | |
| SCHEMBL14320036 | 0.80 | IGF1R (0.45) | IGF1R | |
| SCHEMBL12438489 | 0.78 | IGF1R (0.61) | IGF1R | |
| SCHEMBL4556921 | 0.77 | IGF1R (0.76) | IGF1R | |
| SCHEMBL12438098 | 0.75 | IGF1R (0.46) | IGF1R | |
| SCHEMBL4457351 | 0.73 | IGF1R (0.77) | IGF1R | |
| SCHEMBL12438467 | 0.73 | IGF1R (0.48) | IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1841760-B1 | PYRIMIDINE DERIVATIVES AS KINASE MODULATORS AND METHOD OF USE | EXELIXIS INC (US) | 2011-08-10 | — | — | EP | disclosed |
| WO-2008124161-A1 | METHODS OF TREATING CANCER USING PYRIDOPYRIMIDINONE INHIBITORS OF PI3K ALPHA | EXELIXIS, INC. (US) | 2008-10-16 | — | — | WO | disclosed |