Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 18/20 | 0.64 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15580713 | 0.92 | IGF1R (0.66) | IGF1RPDE10A | |
| SCHEMBL4454739 | 0.91 | IGF1R (0.76) | IGF1RPDE10A | |
| SCHEMBL12437988 | 0.90 | IGF1R (0.62) | IGF1RPDE10A | |
| SCHEMBL15195821 | 0.87 | IGF1R (0.58) | IGF1RPDE10A | |
| SCHEMBL12438520 | 0.83 | IGF1R (0.67) | IGF1R | |
| SCHEMBL12438222 | 0.83 | IGF1R (0.51) | IGF1RLRRK2 | |
| SCHEMBL11344922 | 0.79 | IGF1R (0.76) | IGF1R | |
| SCHEMBL4454742 | 0.79 | IGF1R (0.62) | IGF1R | |
| SCHEMBL4454629 | 0.78 | IGF1R (0.77) | IGF1R | |
| SCHEMBL11342777 | 0.78 | IGF1R (0.77) | IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1841760-B1 | PYRIMIDINE DERIVATIVES AS KINASE MODULATORS AND METHOD OF USE | EXELIXIS INC (US) | 2011-08-10 | — | — | EP | disclosed |
| WO-2008127594-A2 | COMBINATION THERAPIES COMPRISING QUINOXALINE INHIBITORS OF PI3K-ALPHA FOR USE IN THE TREATMENT OF CANCER | EXELIXIS, INC. (US) | 2008-10-23 | — | — | WO | disclosed |
| WO-2008124161-A1 | METHODS OF TREATING CANCER USING PYRIDOPYRIMIDINONE INHIBITORS OF PI3K ALPHA | EXELIXIS, INC. (US) | 2008-10-16 | — | — | WO | disclosed |
| WO-2008076415-A1 | METHODS OF USING MEK INHIBITORS | EXELIXIS, INC. (US) | 2008-06-26 | — | — | WO | disclosed |