Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 18/20 | 0.62 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.37 |
| ▸ | INSR | P06213 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11342777 | 0.89 | IGF1R (0.77) | IGF1RSIRT5 | |
| SCHEMBL4454739 | 0.88 | IGF1R (0.76) | IGF1R | |
| SCHEMBL4458408 | 0.87 | IGF1R (0.79) | IGF1R | |
| SCHEMBL4454629 | 0.87 | IGF1R (0.77) | IGF1RSIRT5 | |
| SCHEMBL11344922 | 0.87 | IGF1R (0.76) | IGF1R | |
| SCHEMBL15256386 | 0.80 | IGF1R (0.70) | IGF1R | |
| SCHEMBL15580713 | 0.80 | IGF1R (0.66) | IGF1R | |
| SCHEMBL11346191 | 0.80 | IGF1R (0.62) | IGF1RINSRMET | |
| SCHEMBL12439769 | 0.80 | IGF1R (0.66) | IGF1RSIRT5 | |
| SCHEMBL12438520 | 0.80 | IGF1R (0.67) | IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |