Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 19/20 | 0.57 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11349278 | 0.94 | IGF1R (0.58) | IGF1RNTRK1JAK2 | |
| SCHEMBL12439373 | 0.92 | IGF1R (0.49) | IGF1R | |
| SCHEMBL12439376 | 0.89 | IGF1R (0.47) | IGF1R | |
| SCHEMBL15095996 | 0.87 | IGF1R (0.62) | IGF1RNTRK1 | |
| SCHEMBL11349785 | 0.84 | IGF1R (0.48) | IGF1R | |
| SCHEMBL12439775 | 0.84 | IGF1R (0.59) | IGF1RNTRK1 | |
| SCHEMBL11340826 | 0.84 | IGF1R (0.69) | IGF1RNTRK1 | |
| SCHEMBL11340156 | 0.83 | IGF1R (0.71) | IGF1RNTRK1 | |
| SCHEMBL14161939 | 0.83 | IGF1R (0.58) | IGF1RNTRK1 | |
| SCHEMBL15256279 | 0.83 | IGF1R (0.58) | IGF1RNTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1841760-B1 | PYRIMIDINE DERIVATIVES AS KINASE MODULATORS AND METHOD OF USE | EXELIXIS INC (US) | 2011-08-10 | — | — | EP | disclosed |
| WO-2008127594-A2 | COMBINATION THERAPIES COMPRISING QUINOXALINE INHIBITORS OF PI3K-ALPHA FOR USE IN THE TREATMENT OF CANCER | EXELIXIS, INC. (US) | 2008-10-23 | — | — | WO | disclosed |
| WO-2008076415-A1 | METHODS OF USING MEK INHIBITORS | EXELIXIS, INC. (US) | 2008-06-26 | — | — | WO | disclosed |
| WO-2008005538-A2 | METHODS OF USING IGF1R AND ABL KINASE MODULATORS | EXELIXIS, INC. (US) | 2008-01-10 | — | — | WO | disclosed |