Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8271878 | 0.88 | KMT2A (0.41) | POLBALDH1A1GRM2PARP1KDM4E | |
| SCHEMBL12441822 | 0.88 | PARP1 (0.42) | ALDH1A1PARP1RAB9AKDM4EHSD17B10 | |
| SCHEMBL12441825 | 0.87 | PARP1 (0.51) | ALDH1A1PARP1 | |
| SCHEMBL8271979 | 0.87 | ALDH1A1 (0.42) | POLBALDH1A1LMNAGRM2RAB9A | |
| SCHEMBL8271580 | 0.85 | PARP1 (0.37) | POLBGRM2PARP1 | |
| SCHEMBL12442810 | 0.85 | PRMT5 (0.39) | ALDH1A1GRM2PARP1KDM4E | |
| SCHEMBL12442218 | 0.85 | GAA (0.42) | POLBALDH1A1LMNAGRM2 | |
| SCHEMBL2023569 | 0.85 | MAPK1 (0.42) | POLBALDH1A1LMNAGRM2RAB9A | |
| SCHEMBL12442013 | 0.83 | GRM2 (0.41) | GRM2PARP1 | |
| SCHEMBL12441824 | 0.83 | PARP1 (0.35) | POLBALDH1A1GRM2PARP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2357169-A1 | Isoindolone compounds and their use as metabotropic glutamate receptor potentiators | AstraZeneca AB (SE) | 2011-08-17 | — | — | EP | disclosed |