Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL764372 | 1.00 | TSHR (0.45) | TSHRSMN1; SMN2CYP1A2POLBHTT | |
| SCHEMBL764343 | 0.84 | PDE3B (0.35) | TSHRSMN1; SMN2CYP1A2 | |
| SCHEMBL765125 | 0.84 | TSHR (0.44) | TSHRSMN1; SMN2CYP1A2POLBHTT | |
| SCHEMBL10046498 | 0.84 | AR (0.38) | TSHRSMN1; SMN2CYP1A2POLBHTT | |
| SCHEMBL765584 | 0.83 | AR (0.36) | TSHRSMN1; SMN2CYP1A2POLB | |
| SCHEMBL10046622 | 0.83 | HTT (0.44) | TSHRSMN1; SMN2CYP1A2POLBHTT | |
| SCHEMBL3319485 | 0.81 | FAAH (0.50) | TSHRSMN1; SMN2POLBKMT2AMEN1 | |
| SCHEMBL3312696 | 0.81 | FAAH (0.50) | TSHRSMN1; SMN2POLBKMT2AMEN1 | |
| SCHEMBL3320407 | 0.81 | FAAH (0.50) | TSHRSMN1; SMN2POLBKMT2AMEN1 | |
| SCHEMBL3312538 | 0.81 | FAAH (0.50) | TSHRSMN1; SMN2POLBKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1919867-B1 | LISOFYLLINE ANALOGUES AND THEIR PHARMEACUETICAL USES | Univ Virginia Patent Found (US) | 2011-08-17 | — | — | EP | disclosed |