Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 6/20 | 0.58 |
| ▸ | JAK2 | O60674 | 10/20 | 0.54 |
| ▸ | CDK9 | P50750 | 3/20 | 0.54 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.54 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.53 |
| ▸ | AURKA | O14965 | 3/20 | 0.52 |
| ▸ | CDK4 | P11802 | 3/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.52 |
| ▸ | CDK1 | P06493 | 3/20 | 0.52 |
| ▸ | KDR | P35968 | 2/20 | 0.52 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.52 |
| ▸ | JAK3 | P52333 | 4/20 | 0.51 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.51 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.51 |
| ▸ | FLT3 | P36888 | 2/20 | 0.50 |
| ▸ | CLK1 | P49759 | 2/20 | 0.50 |
| ▸ | CLK2 | P49760 | 2/20 | 0.50 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2227684 | 0.93 | CDK2 (0.52) | CDK2JAK2CDK9CCNT1ACVR1 | |
| SCHEMBL2227986 | 0.90 | CCNT1 (0.54) | CDK2JAK2CDK9CCNT1ACVR1 | |
| SCHEMBL2542950 | 0.86 | ACVR1 (0.61) | CDK2JAK2CDK9CCNT1ACVR1 | |
| SCHEMBL2541347 | 0.84 | ACVR1 (0.57) | CDK2JAK2CDK9CCNT1ACVR1 | |
| SCHEMBL2229836 | 0.84 | GSK3B (0.51) | CDK2CDK9CCNT1CDK4CDK1 | |
| SCHEMBL12444954 | 0.84 | GSK3B (0.51) | CDK2CDK9CCNT1CDK4CDK1 | |
| SCHEMBL13425118 | 0.83 | GSK3B (0.50) | CDK2CDK9CCNT1AURKACDK4 | |
| SCHEMBL2228372 | 0.83 | GSK3B (0.50) | CDK2CDK9CCNT1AURKACDK4 | |
| SCHEMBL2227733 | 0.83 | GSK3B (0.50) | CDK2CDK9CCNT1CDK4KDR | |
| SCHEMBL2230142 | 0.83 | CDK2 (0.53) | CDK2CDK9CCNT1CDK4CLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110183975-A1 | NOVEL 6-AZAINDOLE AMINOPYRIMIDINE DERIVATIVES HAVING NIK INHIBITORY ACTIVITY | GOTO YASUHIRO | 2011-07-28 | — | — | US | disclosed |
| US-20110183975-A1 | NOVEL 6-AZAINDOLE AMINOPYRIMIDINE DERIVATIVES HAVING NIK INHIBITORY ACTIVITY | GOTO YASUHIRO | 2011-07-28 | — | — | US | disclosed |
| WO-2010042337-A1 | NOVEL 6-AZAINDOLE AMINOPYRIMIDINE DERIVATIVES HAVING NIK INHIBITORY ACTIVITY | MERCK SHARP & DOHME CORP. (US) | 2010-04-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110183975-A1 | NOVEL 6-AZAINDOLE AMINOPYRIMIDINE DERIVATIVES HAVING NIK INHIBITORY ACTIVITY | BRIX1, REL, CNKSR1 | CDK2 381/4885JAK2 708/4885CDK9 428/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.