Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 18/20 | 0.72 |
| ▸ | DDB1 | Q16531 | 17/20 | 0.72 |
| ▸ | IKZF3 | Q9UKT9 | 6/20 | 0.68 |
| ▸ | TNF | P01375 | 1/20 | 0.62 |
| ▸ | IL1B | P01584 | 1/20 | 0.62 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.62 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.56 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | STAT3 | P40763 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26317843 | 0.96 | CRBN (0.78) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL29922394 | 0.93 | CRBN (0.77) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL1097885 | 0.93 | CRBN (0.77) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL1097558 | 0.91 | CRBN (0.74) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL2249753 | 0.91 | CRBN (0.71) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL2248661 | 0.91 | CRBN (0.71) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL31307117 | 0.91 | CRBN (0.65) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL1096542 | 0.89 | CRBN (0.71) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL21087840 | 0.89 | CRBN (0.71) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL30881306 | 0.89 | CRBN (0.68) | CRBNDDB1IKZF3TNFIL1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011100380-A1 | ARYLMETHOXY ISOINDOLINE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME | CELGENE CORPORATION (US) | 2011-08-18 | — | — | WO | disclosed |