Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 18/20 | 0.78 |
| ▸ | DDB1 | Q16531 | 17/20 | 0.78 |
| ▸ | IKZF3 | Q9UKT9 | 6/20 | 0.73 |
| ▸ | TNF | P01375 | 1/20 | 0.64 |
| ▸ | IL1B | P01584 | 1/20 | 0.64 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.64 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.61 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | STAT3 | P40763 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29922394 | 0.97 | CRBN (0.77) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL1097885 | 0.97 | CRBN (0.77) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL12444987 | 0.96 | CRBN (0.72) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL2249753 | 0.95 | CRBN (0.71) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL2248661 | 0.95 | CRBN (0.71) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL1097558 | 0.95 | CRBN (0.74) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL1096542 | 0.93 | CRBN (0.71) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL21087840 | 0.93 | CRBN (0.71) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL30881306 | 0.93 | CRBN (0.68) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL30831085 | 0.92 | CRBN (0.70) | CRBNDDB1IKZF3TNFIL1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11730726-B2 | Dimeric immuno-modulatory compounds against cereblon-based mechanisms | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2023-08-22 | — | — | US | disclosed |
| US-11730726-B2 | Dimeric immuno-modulatory compounds against cereblon-based mechanisms | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2023-08-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11730726-B2 | Dimeric immuno-modulatory compounds against cereblon-based mechanisms | CRBN, CD4, CD74 | CRBN 1/4885DDB1 1404/4885IKZF3 327/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.