Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 5/20 | 0.39 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.33 |
| ▸ | PIK3R2 | O00459 | 4/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.33 |
| ▸ | PIK3R5 | Q8WYR1 | 4/20 | 0.33 |
| ▸ | PIK3R3 | Q92569 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.31 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12449673 | 1.00 | ADRA1A (0.39) | ADRA1AKDM2BPIK3CDPIK3R2PIK3CA | |
| SCHEMBL17828049 | 0.91 | KDM2B (0.41) | ADRA1AKDM2BLMNAALDH1A1KAT2B | |
| SCHEMBL12384482 | 0.85 | ADRA1A (0.39) | ADRA1AKDM2BMEN1POLBMAPT | |
| SCHEMBL12396 | 0.85 | ADRA1A (0.39) | ADRA1AKDM2BMEN1POLBMAPT | |
| SCHEMBL12631 | 0.85 | ADRA1A (0.39) | ADRA1AKDM2BMEN1POLBMAPT | |
| SCHEMBL18664072 | 0.79 | TLR9 (0.34) | POLBLMNAALDH1A1OPRM1 | |
| SCHEMBL17828053 | 0.79 | KDM2B (0.35) | ADRA1AKDM2B | |
| SCHEMBL12449654 | 0.79 | ADRA1A (0.47) | ADRA1AKDM2BLMNAALDH1A1 | |
| SCHEMBL12843 | 0.79 | ADRA1A (0.47) | ADRA1AKDM2BLMNAALDH1A1 | |
| SCHEMBL17828048 | 0.79 | ADRA1A (0.47) | ADRA1AKDM2BLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2499146-B1 | TRICYCLIC PYRAZOL AMINE DERIVATIVES | MERCK SERONO SA (CH) | 2016-09-21 | — | — | EP | disclosed |
| US-9073940-B2 | Tricyclic pyrazol amine derivatives | MERCK SERONO SA (CH) | 2015-07-07 | — | — | US | disclosed |
| US-9073940-B2 | Tricyclic pyrazol amine derivatives | MERCK SERONO SA (CH) | 2015-07-07 | — | — | US | disclosed |
| US-20120238545-A1 | TRICYCLIC PYRAZOL AMINE DERIVATIVES | MERCK SERONO SA (CH) | 2012-09-20 | — | — | US | disclosed |
| US-20120238545-A1 | TRICYCLIC PYRAZOL AMINE DERIVATIVES | MERCK SERONO SA (CH) | 2012-09-20 | — | — | US | disclosed |
| WO-2011058149-A1 | TRICYCLIC PYRAZOL AMINE DERIVATIVES | MERCK SERONO S.A. (CH) | 2011-05-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120238545-A1 | TRICYCLIC PYRAZOL AMINE DERIVATIVES | PI4KB, MTOR, PI4KA | ADRA1A 3308/4885KDM2B 1388/4885PIK3CD 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.