Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 6/20 | 0.46 |
| ▸ | IKZF3 | Q9UKT9 | 5/20 | 0.46 |
| ▸ | HPGD | P15428 | 5/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | AVPR2 | P30518 | 2/20 | 0.41 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18323973 | 0.79 | HPGD (0.55) | HPGDUSP2AVPR2AVPR1AALDH1A1 | |
| SCHEMBL27324085 | 0.77 | CRBN (0.47) | CRBNKMT2AGAADDB1 | |
| SCHEMBL19849591 | 0.74 | CRBN (0.61) | CRBNIKZF3DDB1 | |
| SCHEMBL2256188 | 0.74 | CRBN (0.79) | CRBNIKZF3DDB1 | |
| Hydrochloric Acid SCHEMBL2250435 | 0.73 | CRBN (0.78) | CRBNIKZF3DDB1 | |
| SCHEMBL26027649 | 0.73 | CRBN (0.57) | CRBNIKZF3DDB1 | |
| SCHEMBL27394064 | 0.69 | CRBN (0.49) | CRBNKMT2AGAADDB1 | |
| SCHEMBL23696733 | 0.69 | CRBN (0.41) | CRBNIKZF3PARP1DDB1DRD2 | |
| SCHEMBL27394507 | 0.68 | CRBN (0.36) | CRBNMEN1KMT2ADDB1 | |
| SCHEMBL24113902 | 0.68 | CRBN (0.34) | CRBNIKZF3KMT2AGAADDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011100380-A1 | ARYLMETHOXY ISOINDOLINE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME | CELGENE CORPORATION (US) | 2011-08-18 | — | — | WO | disclosed |