Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 6/20 | 0.55 |
| ▸ | USP2 | O75604 | 2/20 | 0.55 |
| ▸ | AVPR2 | P30518 | 2/20 | 0.50 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12445084 | 0.79 | CRBN (0.46) | HPGDUSP2AVPR2AVPR1AALDH1A1 | |
| SCHEMBL7760917 | 0.74 | GAA (0.58) | HPGDUSP2ALDH1A1ABL1RIN1 | |
| SCHEMBL11955563 | 0.73 | HRH3 (0.66) | HPGDNPC1SMN1; SMN2RAB9AHRH3 | |
| SCHEMBL19608587 | 0.72 | HRH3 (0.61) | HPGDUSP2MAPTNPC1SMN1; SMN2 | |
| SCHEMBL16193403 | 0.72 | MAPK14 (0.38) | HPGDALDH1A1MAPTSMN1; SMN2MEN1 | |
| SCHEMBL10322800 | 0.71 | HPGD (0.59) | HPGDUSP2AVPR2AVPR1AALDH1A1 | |
| SCHEMBL19222209 | 0.71 | ESR2 (0.42) | HRH3POLBMEN1KMT2A | |
| SCHEMBL2377726 | 0.69 | HRH3 (0.64) | HPGDUSP2NPC1SMN1; SMN2HRH3 | |
| SCHEMBL9356201 | 0.69 | HPGD (0.62) | HPGDUSP2ALDH1A1ABL1RIN1 | |
| SCHEMBL1649233 | 0.69 | HPGD (0.56) | HPGDUSP2AVPR2AVPR1AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4289838-A2 | ARYLMETHOXY ISOINDOLINE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME | Celgene Corporation (US) | 2023-12-13 | — | — | EP | disclosed |
| EP-3599236-A1 | ARYLMETHOXY ISOINDOLINE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME | Celgene Corporation (US) | 2020-01-29 | — | — | EP | disclosed |
| EP-3202461-A1 | ARYLMETHOXY ISOINDOLINE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME | Celgene Corporation (US) | 2017-08-09 | — | — | EP | disclosed |
| EP-3202460-A1 | ARYLMETHOXY ISOINDOLINE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME | Celgene Corporation (US) | 2017-08-09 | — | — | EP | disclosed |
| EP-3106460-A1 | ARYLMETHOXY ISOINDOLINE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME | Celgene Corporation (US) | 2016-12-21 | — | — | EP | disclosed |