Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 19/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12301419 | 0.85 | BACE1 (0.73) | BACE1MEN1KMT2A | |
| SCHEMBL12445836 | 0.84 | BACE1 (0.49) | BACE1 | |
| SCHEMBL287106 | 0.80 | BACE1 (0.70) | BACE1 | |
| SCHEMBL12445800 | 0.79 | BACE1 (0.65) | BACE1 | |
| SCHEMBL12446182 | 0.78 | BACE1 (0.56) | BACE1 | |
| SCHEMBL12446168 | 0.77 | BACE1 (0.51) | BACE1MEN1KMT2A | |
| SCHEMBL12445773 | 0.76 | BACE1 (0.50) | BACE1 | |
| SCHEMBL297169 | 0.76 | BACE1 (0.48) | BACE1 | |
| SCHEMBL12446197 | 0.76 | GLA (0.52) | BACE1MEN1KMT2A | |
| SCHEMBL12445535 | 0.76 | BACE1 (0.66) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2360155-A1 | 2-AMINOPYRIDIN-4-ONE AND 2-AMINOPYRIDINE DERIVATIVE BOTH HAVING BACE1-INHIBITING ACTIVITY | Shionogi & Co., Ltd. (JP) | 2011-08-24 | — | — | EP | disclosed |