Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12303291 | 0.83 | BACE1 (0.60) | BACE1CYP2D6BACE2 | |
| SCHEMBL12446176 | 0.81 | BACE1 (0.57) | BACE1BACE2 | |
| SCHEMBL12445623 | 0.81 | BACE1 (0.53) | BACE1BACE2 | |
| SCHEMBL1976782 | 0.80 | BACE1 (0.73) | BACE1CYP2D6BACE2 | |
| SCHEMBL4077508 | 0.80 | BACE1 (0.72) | BACE1BACE2 | |
| SCHEMBL4088227 | 0.79 | BACE1 (0.77) | BACE1BACE2 | |
| SCHEMBL1173322 | 0.79 | BACE1 (0.81) | BACE1BACE2 | |
| SCHEMBL2588183 | 0.79 | BACE1 (0.71) | BACE1CYP2D6BACE2 | |
| SCHEMBL12445836 | 0.77 | BACE1 (0.49) | BACE1BACE2 | |
| Formic Acid SCHEMBL2592659 | 0.76 | BACE1 (0.67) | BACE1CYP2D6BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2360155-A1 | 2-AMINOPYRIDIN-4-ONE AND 2-AMINOPYRIDINE DERIVATIVE BOTH HAVING BACE1-INHIBITING ACTIVITY | Shionogi & Co., Ltd. (JP) | 2011-08-24 | — | — | EP | disclosed |