Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 17/20 | 0.55 |
| ▸ | ATR | Q13535 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7944151 | 0.86 | BACE1 (0.57) | BACE1ATRHDAC3HDAC2 | |
| SCHEMBL12445669 | 0.83 | BACE1 (0.40) | BACE1 | |
| SCHEMBL12445785 | 0.82 | BACE1 (0.51) | BACE1 | |
| SCHEMBL12445678 | 0.81 | BACE1 (0.42) | BACE1 | |
| SCHEMBL12445801 | 0.79 | NPC1 (0.44) | BACE1 | |
| SCHEMBL12445791 | 0.79 | BACE1 (0.47) | BACE1 | |
| SCHEMBL12446242 | 0.76 | BACE1 (0.44) | BACE1 | |
| SCHEMBL12446238 | 0.76 | BACE1 (0.56) | BACE1 | |
| SCHEMBL12445687 | 0.74 | KMT2A (0.46) | BACE1 | |
| SCHEMBL7941196 | 0.74 | BACE1 (0.74) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2360155-A1 | 2-AMINOPYRIDIN-4-ONE AND 2-AMINOPYRIDINE DERIVATIVE BOTH HAVING BACE1-INHIBITING ACTIVITY | Shionogi & Co., Ltd. (JP) | 2011-08-24 | — | — | EP | disclosed |