Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 11/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | LIG1 | P18858 | 1/20 | 0.32 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | TYK2 | P29597 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | TLK2 | Q86UE8 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12445802 | 0.87 | BACE1 (0.47) | BACE1KMT2AMEN1MAPTNPC1 | |
| SCHEMBL7946593 | 0.84 | BACE1 (0.47) | BACE1 | |
| SCHEMBL12445678 | 0.81 | BACE1 (0.42) | BACE1 | |
| SCHEMBL12446250 | 0.79 | BACE1 (0.48) | BACE1KMT2AMEN1KDM4EMAPT | |
| SCHEMBL12445785 | 0.77 | BACE1 (0.51) | BACE1BACE2 | |
| SCHEMBL12445687 | 0.77 | KMT2A (0.46) | BACE1KMT2AMEN1MAPTNPC1 | |
| SCHEMBL12445801 | 0.77 | NPC1 (0.44) | BACE1MAPTNPC1ALDH1A1RAB9A | |
| SCHEMBL12446242 | 0.75 | BACE1 (0.44) | BACE1KMT2AMEN1KDM4ERAB9A | |
| SCHEMBL12445808 | 0.74 | NPC1 (0.47) | BACE1KDM4ENPC1ALDH1A1RAB9A | |
| SCHEMBL12445643 | 0.73 | BACE1 (0.49) | BACE1APPBACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2360155-A1 | 2-AMINOPYRIDIN-4-ONE AND 2-AMINOPYRIDINE DERIVATIVE BOTH HAVING BACE1-INHIBITING ACTIVITY | Shionogi & Co., Ltd. (JP) | 2011-08-24 | — | — | EP | disclosed |