Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 9/20 | 0.43 |
| ▸ | RAB9A | P51151 | 9/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.43 |
| ▸ | MEN1 | O00255 | 7/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.41 |
| ▸ | CASP3 | P42574 | 4/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 4/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.41 |
| ▸ | RELA | Q04206 | 3/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12445672 | 0.87 | BACE1 (0.49) | BACE1NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL12301731 | 0.83 | BACE1 (0.48) | BACE1NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL12446250 | 0.80 | BACE1 (0.48) | BACE1NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL12445785 | 0.79 | BACE1 (0.51) | BACE1 | |
| SCHEMBL12445801 | 0.78 | NPC1 (0.44) | BACE1NPC1RAB9AUSP2SMN1; SMN2 | |
| SCHEMBL12445687 | 0.78 | KMT2A (0.46) | BACE1NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL12445678 | 0.77 | BACE1 (0.42) | BACE1 | |
| SCHEMBL12446242 | 0.77 | BACE1 (0.44) | BACE1RAB9AKMT2AMEN1 | |
| SCHEMBL12445808 | 0.76 | NPC1 (0.47) | BACE1NPC1RAB9ASMN1; SMN2MAPK1 | |
| SCHEMBL12445643 | 0.75 | BACE1 (0.49) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2360155-A1 | 2-AMINOPYRIDIN-4-ONE AND 2-AMINOPYRIDINE DERIVATIVE BOTH HAVING BACE1-INHIBITING ACTIVITY | Shionogi & Co., Ltd. (JP) | 2011-08-24 | — | — | EP | disclosed |