Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 15/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7933972 | 0.85 | BACE1 (0.52) | BACE1MAPTKDM4EALDH1A1GAA | |
| SCHEMBL12446176 | 0.79 | BACE1 (0.57) | BACE1BACE2 | |
| SCHEMBL7943380 | 0.78 | BACE1 (0.53) | BACE1MAPTKDM4EALDH1A1GAA | |
| SCHEMBL12302218 | 0.78 | BACE1 (0.53) | BACE1MAPTKDM4EALDH1A1GAA | |
| SCHEMBL7942669 | 0.77 | BACE1 (0.54) | BACE1BACE2 | |
| SCHEMBL7943378 | 0.77 | BACE1 (0.62) | BACE1MAPTKDM4EALDH1A1GAA | |
| SCHEMBL7944886 | 0.76 | BACE1 (0.52) | BACE1BACE2 | |
| SCHEMBL7944999 | 0.75 | BACE1 (0.54) | BACE1MAPTKDM4EALDH1A1BACE2 | |
| SCHEMBL12445623 | 0.75 | BACE1 (0.53) | BACE1BACE2 | |
| SCHEMBL12445579 | 0.74 | BACE1 (0.60) | BACE1BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2360155-A1 | 2-AMINOPYRIDIN-4-ONE AND 2-AMINOPYRIDINE DERIVATIVE BOTH HAVING BACE1-INHIBITING ACTIVITY | Shionogi & Co., Ltd. (JP) | 2011-08-24 | — | — | EP | disclosed |