Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS4 | O75173 | 8/20 | 0.44 |
| ▸ | ADAMTS5 | Q9UNA0 | 8/20 | 0.44 |
| ▸ | MMP2 | P08253 | 8/20 | 0.42 |
| ▸ | MMP3 | P08254 | 7/20 | 0.42 |
| ▸ | MMP13 | P45452 | 7/20 | 0.42 |
| ▸ | MMP14 | P50281 | 7/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | ADAM17 | P78536 | 5/20 | 0.41 |
| ▸ | MMP9 | P14780 | 3/20 | 0.41 |
| ▸ | MMP1 | P03956 | 2/20 | 0.41 |
| ▸ | MMP7 | P09237 | 2/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.40 |
| ▸ | BACE1 | P56817 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7940948 | 0.85 | BACE1 (0.53) | ADAMTS4ADAMTS5MMP2MMP3MMP13 | |
| SCHEMBL12445785 | 0.83 | BACE1 (0.51) | BACE1 | |
| SCHEMBL12445801 | 0.78 | NPC1 (0.44) | BACE1NPC1TP53RAB9ANFKB1 | |
| SCHEMBL12445678 | 0.75 | BACE1 (0.42) | BACE1 | |
| SCHEMBL12446242 | 0.75 | BACE1 (0.44) | BACE1RAB9AKDM4E | |
| SCHEMBL12446250 | 0.75 | BACE1 (0.48) | L3MBTL1BACE1NPC1TP53RAB9A | |
| SCHEMBL12445687 | 0.75 | KMT2A (0.46) | BACE1NPC1TP53RAB9ANFKB1 | |
| SCHEMBL7944780 | 0.75 | NPC1 (0.46) | MMP2MMP13BACE1NPC1TP53 | |
| SCHEMBL12445808 | 0.74 | NPC1 (0.47) | BACE1NPC1RAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL12445802 | 0.74 | BACE1 (0.47) | L3MBTL1BACE1NPC1TP53RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2360155-A1 | 2-AMINOPYRIDIN-4-ONE AND 2-AMINOPYRIDINE DERIVATIVE BOTH HAVING BACE1-INHIBITING ACTIVITY | Shionogi & Co., Ltd. (JP) | 2011-08-24 | — | — | EP | disclosed |