Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.45 |
| ▸ | TEAD1 | P28347 | 2/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | PIK3R5 | Q8WYR1 | 1/20 | 0.41 |
| ▸ | PIK3R3 | Q92569 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | DRD4 | P21917 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12449566 | 0.86 | MEN1 (0.43) | MCHR1SIGMAR1TEAD1PIK3CDPIK3R2 | |
| SCHEMBL12450 | 0.86 | SIGMAR1 (0.51) | SIGMAR1PIK3CDPIK3R2PIK3CAPIK3CB | |
| SCHEMBL12449583 | 0.81 | MCHR1 (0.55) | MCHR1SIGMAR1TEAD1MEN1KMT2A | |
| SCHEMBL18082557 | 0.77 | TMEM97 (0.48) | SIGMAR1PIK3CDPIK3R2PIK3CAPIK3CB | |
| SCHEMBL25531003 | 0.76 | SIGMAR1 (0.50) | MCHR1SIGMAR1TEAD1MEN1KMT2A | |
| SCHEMBL12449546 | 0.76 | TEAD1 (0.54) | MCHR1SIGMAR1TEAD1MEN1KMT2A | |
| SCHEMBL797735 | 0.74 | SIGMAR1 (0.60) | MCHR1SIGMAR1TEAD1MEN1KMT2A | |
| SCHEMBL25531180 | 0.74 | SIGMAR1 (0.60) | MCHR1SIGMAR1TEAD1MEN1KMT2A | |
| SCHEMBL25531010 | 0.74 | TEAD1 (0.52) | MCHR1SIGMAR1TEAD1MEN1KMT2A | |
| SCHEMBL25531179 | 0.74 | SIGMAR1 (0.60) | MCHR1SIGMAR1TEAD1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9073940-B2 | Tricyclic pyrazol amine derivatives | MERCK SERONO SA (CH) | 2015-07-07 | — | — | US | disclosed |
| US-9073940-B2 | Tricyclic pyrazol amine derivatives | MERCK SERONO SA (CH) | 2015-07-07 | — | — | US | disclosed |
| US-20120238545-A1 | TRICYCLIC PYRAZOL AMINE DERIVATIVES | MERCK SERONO SA (CH) | 2012-09-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120238545-A1 | TRICYCLIC PYRAZOL AMINE DERIVATIVES | PI4KB, MTOR, PI4KA | MCHR1 4731/4885SIGMAR1 3225/4885TEAD1 602/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.