Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.30 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.30 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.30 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1087893 | 0.82 | HSD11B1 (0.36) | HSD11B1 | |
| SCHEMBL2278967 | 0.82 | HSD11B1 (0.36) | HSD11B1 | |
| SCHEMBL12372508 | 0.81 | HSD11B1 (0.32) | HSD11B1 | |
| SCHEMBL17929003 | 0.74 | MAPT (0.37) | HSD11B1 | |
| SCHEMBL5595209 | 0.71 | GRM1 (0.33) | TDP1 | |
| SCHEMBL4194876 | 0.69 | — | — | |
| SCHEMBL26052884 | 0.69 | — | — | |
| SCHEMBL28486688 | 0.68 | HSD11B1 (0.30) | HSD11B1 | |
| Hydrochloric Acid SCHEMBL28293251 | 0.67 | TDP1 (0.34) | TDP1PDK1PDK2PDK3PDK4 | |
| Acetic Acid SCHEMBL28226143 | 0.67 | HSD11B1 (0.39) | HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245033-B1 | PYRROLOPYRAZINE KINASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2011-08-31 | — | — | EP | disclosed |