Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | NOD1 | Q9Y239 | 3/20 | 0.37 |
| ▸ | NOD2 | Q9HC29 | 2/20 | 0.37 |
| ▸ | CXCL8 | P10145 | 2/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL459216 | 0.84 | MEN1 (0.46) | HTR6MAPTKMT2AMEN1HTT | |
| SCHEMBL458467 | 0.83 | HTR6 (0.43) | HTR6MAPTKMT2AMEN1HTT | |
| SCHEMBL12970761 | 0.80 | HTR6 (0.59) | HTR6MAPTKMT2AMEN1HTT | |
| SCHEMBL1118681 | 0.79 | MAPT (0.47) | MAPTKMT2AMEN1SLC9A1GAA | |
| SCHEMBL470192 | 0.78 | NR1H2 (0.41) | HTR6MAPTKMT2AMEN1HTT | |
| SCHEMBL14665921 | 0.76 | HTR6 (0.45) | HTR6MAPTKMT2AMEN1HTT | |
| SCHEMBL1958201 | 0.75 | PIK3CG (0.48) | HTR6 | |
| SCHEMBL1959668 | 0.75 | HTR6 (0.36) | HTR6MAPTKMT2AMEN1HTT | |
| SCHEMBL10280415 | 0.75 | PIK3C3 (0.41) | HTR6MAPTKMT2AMEN1HTT | |
| SCHEMBL1431296 | 0.75 | HTR6 (0.39) | HTR6MAPTKMT2AMEN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120238571-A1 | INDAZOLE DERIVATIVES AS PI 3-KINASE | GLAXO GROUP LIMITED (GB) | 2012-09-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120238571-A1 | INDAZOLE DERIVATIVES AS PI 3-KINASE | PI4KA, PIP4K2B, PI4KB | HTR6 4240/4885MAPT 1784/4885KMT2A 2938/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.