Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 16/20 | 0.64 |
| ▸ | CDC37 | Q16543 | 7/20 | 0.64 |
| ▸ | HSP90B1 | P14625 | 5/20 | 0.56 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.56 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12454399 | 0.87 | HSP90AA1 (0.59) | HSP90AA1CDC37HSP90B1TRAP1 | |
| SCHEMBL14084824 | 0.85 | HSP90AA1 (0.63) | HSP90AA1CDC37HSP90B1HSP90AB1TRAP1 | |
| SCHEMBL12454418 | 0.85 | HSP90AA1 (0.49) | HSP90AA1CDC37HSP90B1TRAP1 | |
| SCHEMBL17897906 | 0.83 | HSP90B1 (0.79) | HSP90AA1HSP90B1HSP90AB1TRAP1 | |
| SCHEMBL12454404 | 0.83 | HSP90AA1 (0.61) | HSP90AA1CDC37HSP90B1HSP90AB1TRAP1 | |
| SCHEMBL14084826 | 0.82 | HSP90AA1 (0.80) | HSP90AA1CDC37 | |
| SCHEMBL12454437 | 0.81 | HSP90AA1 (0.55) | HSP90AA1CDC37HSP90B1HSP90AB1TRAP1 | |
| SCHEMBL12454412 | 0.80 | HSP90AA1 (0.45) | HSP90AA1CDC37HSP90B1TRAP1 | |
| SCHEMBL12454440 | 0.79 | HSP90AA1 (0.49) | HSP90AA1CDC37HSP90B1TRAP1 | |
| SCHEMBL12454421 | 0.79 | HSP90AA1 (0.64) | HSP90AA1CDC37HSP90B1TRAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230192687-A1 | FUSED AMINO PYRIDINE AS HSP90 INHIBITORS | CURIS INC (US) | 2023-06-22 | — | — | US | disclosed |
| US-10035797-B2 | Fused amino pyridine as HSP90 inhibitors | CURIS, INC. (US) | 2018-07-31 | — | — | US | disclosed |
| US-20170267674-A1 | FUSED AMINO PYRIDINE AS HSP90 INHIBITORS | CURIS INC (US) | 2017-09-21 | — | — | US | disclosed |
| US-9630965-B2 | Fused amino pyridine as HSP90 inhibitors | CURIS, INC. (US) | 2017-04-25 | — | — | US | disclosed |
| US-20170002002-A1 | FUSED AMINO PYRIDINE AS HSP90 INHIBITORS | CURIS INC (US) | 2017-01-05 | — | — | US | disclosed |
| US-9402832-B2 | Fused amino pyridine as HSP90 inhibitors | CURIS, INC. (US) | 2016-08-02 | — | — | US | disclosed |
| US-20160058742-A1 | FUSED AMINO PYRIDINE AS HSP90 INHIBITORS | CURIS INC (US) | 2016-03-03 | — | — | US | disclosed |
| US-9040556-B2 | Fused amino pyridine as HSP90 inhibitors | CURIS, INC. (US) | 2015-05-26 | — | — | US | disclosed |
| US-20140221343-A1 | FUSED AMINO PYRIDINE AS HSP90 INHIBITORS | CURIS, INC. (US) | 2014-08-07 | — | — | US | disclosed |
| US-8586605-B2 | Fused amino pyridine as HSP90 inhibitors | CURIS, INC. (US) | 2013-11-19 | — | — | US | disclosed |
| US-8324240-B2 | Fused amino pyridine as HSP90 inhibitors | CURIS, INC. (US) | 2012-12-04 | — | — | US | disclosed |
| US-20120237508-A1 | FUSED AMINO PYRIDINE AS HSP90 INHIBITORS | CURIS, INC. | 2012-09-20 | — | — | US | disclosed |
| US-20080234314-A1 | FUSED AMINO PYRIDINE AS HSP90 INHIBITORS | CURIS, INC. | 2008-09-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170267674-A1 | FUSED AMINO PYRIDINE AS HSP90 INHIBITORS | HSP90B1, HSP90AB1, HSP90AB2P | HSP90AA1 4/4885CDC37 5/4885HSP90B1 1/4885 |
| US-20160058742-A1 | FUSED AMINO PYRIDINE AS HSP90 INHIBITORS | HSP90B1, HSP90AB1, HSP90AB2P | HSP90AA1 4/4885CDC37 5/4885HSP90B1 1/4885 |
| US-20120237508-A1 | FUSED AMINO PYRIDINE AS HSP90 INHIBITORS | HSP90B1, HSP90AB1, HSP90AB2P | HSP90AA1 4/4885CDC37 5/4885HSP90B1 1/4885 |
| US-20170002002-A1 | FUSED AMINO PYRIDINE AS HSP90 INHIBITORS | HSP90B1, HSP90AB1, HSP90AB2P | HSP90AA1 4/4885CDC37 5/4885HSP90B1 1/4885 |
| US-20230192687-A1 | FUSED AMINO PYRIDINE AS HSP90 INHIBITORS | HSP90B1, HSP90AB1, HSP90AB2P | HSP90AA1 4/4885CDC37 5/4885HSP90B1 1/4885 |
| US-20080234314-A1 | FUSED AMINO PYRIDINE AS HSP90 INHIBITORS | HSP90B1, HSP90AB1, HSP90AB2P | HSP90AA1 4/4885CDC37 5/4885HSP90B1 1/4885 |
| US-20140221343-A1 | FUSED AMINO PYRIDINE AS HSP90 INHIBITORS | HSP90B1, HSP90AB1, HSP90AB2P | HSP90AA1 4/4885CDC37 5/4885HSP90B1 1/4885 |
| US-10035797-B2 | Fused amino pyridine as HSP90 inhibitors | HSP90B1, HSP90AB1, HSP90AB2P | HSP90AA1 4/4885CDC37 5/4885HSP90B1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.