Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.36 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.36 |
| ▸ | CCR3 | P51677 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | AKT1 | P31749 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL895335 | 0.94 | SMN1; SMN2 (0.38) | SMN1; SMN2PLA2G1BATG4BCCR3HDAC1 | |
| SCHEMBL895333 | 0.94 | SMN1; SMN2 (0.38) | SMN1; SMN2PLA2G1BATG4BCCR3HDAC1 | |
| SCHEMBL29368845 | 0.94 | SMN1; SMN2 (0.38) | SMN1; SMN2PLA2G1BATG4BCCR3HDAC1 | |
| SCHEMBL12459710 | 0.92 | SMN1; SMN2 (0.37) | SMN1; SMN2PLA2G1BATG4BCCR3HDAC1 | |
| SCHEMBL12459709 | 0.91 | SMN1; SMN2 (0.35) | SMN1; SMN2PLA2G1BATG4BHDAC1HDAC6 | |
| SCHEMBL13837491 | 0.91 | SMN1; SMN2 (0.35) | SMN1; SMN2PLA2G1BATG4BHDAC1HDAC6 | |
| SCHEMBL12459607 | 0.91 | SMN1; SMN2 (0.36) | SMN1; SMN2PLA2G1BATG4BHDAC1HDAC6 | |
| SCHEMBL12459579 | 0.91 | NOTUM (0.40) | SMN1; SMN2PLA2G1BATG4BCCR3HDAC1 | |
| SCHEMBL13969000 | 0.90 | CYP3A4 (0.39) | SMN1; SMN2PLA2G1BATG4BHDAC1HDAC6 | |
| SCHEMBL12459608 | 0.90 | SMN1; SMN2 (0.39) | SMN1; SMN2HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011095581-A1 | S PIROINDOLINE COMPOUNDS FOR USE AS ANTHELMINTHI CS | INTERVET INTERNATIONAL B.V. (NL) | 2011-08-11 | — | — | WO | disclosed |