SCHEMBL895335

SCHEMBL895335

O=C(c1ccnc(Cl)c1)N1CC2(CCN(CC=Cc3ccc(Cl)cc3)CC2)c2cc(F)ccc21

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 1/20 0.38
DRD2 P14416 2/20 0.37
EBP Q15125 1/20 0.37
SIGMAR1 Q99720 1/20 0.37
NOTUM Q6P988 1/20 0.36
PROKR1 Q8TCW9 1/20 0.35
HDAC1 Q13547 1/20 0.35
HDAC6 Q9UBN7 1/20 0.35
PLA2G1B P04054 1/20 0.35
ATG4B Q9Y4P1 1/20 0.35
DHCR7 Q9UBM7 1/20 0.35
CCR3 P51677 1/20 0.34
LMNA P02545 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29368845 1.00 SMN1; SMN2 (0.38) SMN1; SMN2DRD2EBPSIGMAR1NOTUM
SCHEMBL895333 1.00 SMN1; SMN2 (0.38) SMN1; SMN2DRD2EBPSIGMAR1NOTUM
SCHEMBL12459579 0.95 NOTUM (0.40) SMN1; SMN2DRD2EBPSIGMAR1NOTUM
SCHEMBL13837491 0.94 SMN1; SMN2 (0.35) SMN1; SMN2NOTUMHDAC1HDAC6PLA2G1B
SCHEMBL12459709 0.94 SMN1; SMN2 (0.35) SMN1; SMN2NOTUMHDAC1HDAC6PLA2G1B
SCHEMBL12459710 0.94 SMN1; SMN2 (0.37) SMN1; SMN2NOTUMHDAC1HDAC6PLA2G1B
SCHEMBL12459583 0.94 SMN1; SMN2 (0.37) SMN1; SMN2HDAC1HDAC6PLA2G1BATG4B
SCHEMBL13968936 0.93 NOTUM (0.42) SMN1; SMN2EBPSIGMAR1NOTUMPROKR1
SCHEMBL12459607 0.93 SMN1; SMN2 (0.36) SMN1; SMN2NOTUMHDAC1HDAC6PLA2G1B
SCHEMBL15771957 0.92 DRD2 (0.35) SMN1; SMN2DRD2EBPSIGMAR1NOTUM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 582 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3701796-A1 ACTIVE COMPOUND COMBINATIONS Bayer AG (DE) 2020-09-02 EP claimed
US-20200236938-A1 ACTIVE COMPOUND COMBINATIONS HAVING INSECTICIDAL/ACARICIDAL PROPERTIES BAYER AKTIENGESELLSCHAFT (DE) 2020-07-30 US claimed
EP-3473100-A1 ACTIVE COMPOUND COMBINATIONS HAVING INSECTICIDAL/ACARICIDAL PROPERTIES Bayer Aktiengesellschaft (DE) 2019-04-24 EP claimed
EP-3010889-B1 ARYLSULFIDE AND ARYLSULFOXIDE DERIVATIVES AS ACARICIDES AND INSECTICIDES BAYER CROPSCIENCE AG (DE) 2018-10-03 EP claimed
EP-2793578-B1 N-ARYLAMIDINE-SUBSTITUTED TRIFLUOROETHYLSULFIDE DERIVATIVES AS ACARICIDES AND INSECTICIDES BAYER CROPSCIENCE AG (DE) 2018-06-06 EP claimed
EP-2925142-B1 COMPOSITION COMPRISING A BIOLOGICAL CONTROL AGENT AND AN INSECTICIDE BAYER CROPSCIENCE AG (DE) 2018-01-31 EP claimed
US-9867377-B2 Composition comprising a biological control agent and an insecticide BAYER CROPSCIENCE AG (DE) 2018-01-16 US claimed
US-20170265479-A1 COMPOSITION COMPRISING BIOLOGICAL CONTROL AGENTS BAYER CROPSCIENCE AG (DE) 2017-09-21 US claimed
US-9693565-B2 Composition comprising biological control agents BAYER CROPSCIENCE AG (DE) 2017-07-04 US claimed
US-20160262401-A1 COMPOSITIONS COMPRISING A BIOLOGICAL CONTROL AGENT AND AN INSECTICIDE BAYER CROPSCIENCE AG (DE) 2016-09-15 US claimed
US-20150305348-A1 COMPOSITION COMPRISING BIOLOGICAL CONTROL AGENTS BAYER CROPSCIENCE AG (DE) 2015-10-29 US claimed
US-20150296804-A1 COMPOSITION COMPRISING BIOLOGICAL CONTROL AGENTS DANSTAR FERMENT AG (CH) 2015-10-22 US claimed
US-20150289518-A1 COMPOSITION COMPRISING A BIOLOGICAL CONTROL AGENT AND AN INSECTICIDE BAYER CROPSCIENCE AG (DE) 2015-10-15 US claimed
US-20150189882-A1 ACTIVE INGREDIENT COMBINATIONS HAVING INSECTICIDAL AND ACARICIDAL PROPERTIES BAYER INTELLECTUAL PROPERTY GMBH 2015-07-09 US claimed
US-20150148230-A1 COMPOSITIONS COMPRISING A BIOLOGICAL CONTROL AGENT AND AN INSECTICIDE BAYER CROPSCIENCE AG (DE) 2015-05-28 US claimed
US-20140315898-A1 N-ARYLAMIDINE-SUBSTITUTED TRIFLUOROETHYL SULFIDE DERIVATIVES AS ACARICIDES AND INSECTICIDES BAYER CROPSCIENCE AG (DE) 2014-10-23 US claimed
US-20140310835-A1 SOYBEAN EVENT SYHT04R AND COMPOSITIONS AND METHODS FOR DETECTION THEREOF SYNGENTA PARTICIPATIONS AG (CH) 2014-10-16 US claimed
US-20140051576-A1 ACTIVE COMPOUND COMBINATIONS COMPRISING A (THIO)CARBOXAMIDE DERIVATIVE AND AN INSECTICIDAL OR ACARICIDAL OR NEMATICIDAL ACTIVE COMPOUND BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2014-02-20 US claimed
EP-2604118-A1 Active ingredient combinations having insecticidal and acaricidal properties Bayer CropScience AG (DE) 2013-06-19 EP claimed
US-20110311503-A1 Active ingredient combinations having insecticidal and acaricidal properties BAYER CROPSCIENCE AG (DE) 2011-12-22 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140315898-A1 N-ARYLAMIDINE-SUBSTITUTED TRIFLUOROETHYL SULFIDE DERIVATIVES AS ACARICIDES AND INSECTICIDES AFF4, ARSA, AFF1 SMN1; SMN2 711/4885DRD2 3848/4885EBP 2653/4885
US-20150189882-A1 ACTIVE INGREDIENT COMBINATIONS HAVING INSECTICIDAL AND ACARICIDAL PROPERTIES ACHE, AADAC, ACAT2 SMN1; SMN2 675/4885DRD2 4426/4885EBP 568/4885
US-20200236938-A1 ACTIVE COMPOUND COMBINATIONS HAVING INSECTICIDAL/ACARICIDAL PROPERTIES ACHE, CYP51A1, ACAT1 SMN1; SMN2 2530/4885DRD2 4260/4885EBP 676/4885
US-20150148230-A1 COMPOSITIONS COMPRISING A BIOLOGICAL CONTROL AGENT AND AN INSECTICIDE DDT, ACHE, BROX SMN1; SMN2 2634/4885DRD2 2917/4885EBP 1634/4885
US-20160262401-A1 COMPOSITIONS COMPRISING A BIOLOGICAL CONTROL AGENT AND AN INSECTICIDE O60361, GAP43, BMP4 SMN1; SMN2 1020/4885DRD2 1598/4885EBP 1528/4885
US-20140051576-A1 ACTIVE COMPOUND COMBINATIONS COMPRISING A (THIO)CARBOXAMIDE DERIVATIVE AND AN INSECTICIDAL OR ACARICIDAL OR NEMATICIDAL ACTIVE COMPOUND AADAC, TUBA3C, ACACA SMN1; SMN2 2982/4885DRD2 2471/4885EBP 2151/4885
US-20110311503-A1 Active ingredient combinations having insecticidal and acaricidal properties ACHE, ACAT1, ACAT2 SMN1; SMN2 1190/4885DRD2 4580/4885EBP 177/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.