Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | ACACB | O00763 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14817913 | 0.85 | MMP13 (0.53) | MMP13MEN1KMT2ANAMPTPDK1 | |
| SCHEMBL13211819 | 0.80 | MMP13 (0.84) | MMP13MEN1KMT2ANAMPTMAPK14 | |
| SCHEMBL18773998 | 0.78 | MEN1 (0.61) | MMP13MEN1KMT2ANAMPTROCK2 | |
| SCHEMBL11187328 | 0.75 | KMT2A (0.66) | MMP13MEN1KMT2ANAMPTROCK2 | |
| SCHEMBL31660043 | 0.75 | MMP13 (0.60) | MMP13MEN1KMT2ANAMPTROCK2 | |
| SCHEMBL12599208 | 0.74 | NPC1 (0.49) | MEN1KMT2AALDH1A1HSP90AA1HPGD | |
| SCHEMBL14817967 | 0.74 | GAA (0.63) | MMP13MEN1KMT2AMAPK14ALDH1A1 | |
| SCHEMBL30633434 | 0.74 | MEN1 (0.60) | MMP13MEN1KMT2ANAMPTROCK2 | |
| SCHEMBL26981033 | 0.74 | MEN1 (0.60) | MMP13MEN1KMT2ANAMPTROCK2 | |
| SCHEMBL10268291 | 0.74 | KMT2A (0.64) | MMP13MEN1KMT2ANAMPTROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1802636-B1 | PI3 KINASES INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2013-03-27 | — | — | EP | disclosed |
| EP-2343303-A1 | PI3-kinase inhibitors | Boehringer Ingelheim International GmbH (DE) | 2011-07-13 | — | — | EP | disclosed |