Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 7/20 | 0.46 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.37 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.37 |
| ▸ | MERTK | Q12866 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13203952 | 0.87 | NOTUM (0.43) | OPRL1SLC18A3SIGMAR1NOTUMHSD11B1 | |
| SCHEMBL12316031 | 0.86 | HSD11B1 (0.39) | SLC18A3SIGMAR1NOTUMHSD11B1AXL | |
| SCHEMBL13203975 | 0.85 | NOTUM (0.42) | SLC18A3SIGMAR1NOTUMHSD11B1AXL | |
| SCHEMBL1713339 | 0.84 | AXL (0.43) | SLC18A3SIGMAR1NOTUMHSD11B1AXL | |
| SCHEMBL12315863 | 0.83 | HSD11B1 (0.41) | OPRL1NOTUMHSD11B1KDM1A | |
| SCHEMBL12315886 | 0.82 | OPRL1 (0.39) | OPRL1SLC18A3SIGMAR1NOTUMHSD11B1 | |
| SCHEMBL12315864 | 0.81 | CHRM1 (0.47) | — | |
| SCHEMBL12315887 | 0.81 | CHRM1 (0.46) | KDM1A | |
| SCHEMBL12316020 | 0.81 | KDM1A (0.50) | HSD11B1OPRM1KDM1A | |
| SCHEMBL13203982 | 0.80 | SLC18A3 (0.42) | OPRL1SLC18A3SIGMAR1NOTUMHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1987034-B1 | SPIRO CONDENSED PIPERIDINES AS MODULATORS OF MUSCARINIC RECEPTORS | VERTEX PHARMA (US) | 2011-07-20 | — | — | EP | disclosed |