Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2C | P18825 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 6/20 | 0.40 |
| ▸ | FLT1 | P17948 | 5/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KIT | P10721 | 3/20 | 0.37 |
| ▸ | ABL1 | P00519 | 2/20 | 0.37 |
| ▸ | CSF1R | P07333 | 2/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.37 |
| ▸ | FLT4 | P35916 | 2/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 2/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.36 |
| ▸ | PRKACA | P17612 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | CLK2 | P49760 | 1/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1715084 | 0.89 | KDR (0.45) | ADRA2CKDRFLT1ABCB1ALDH1A1 | |
| SCHEMBL12461049 | 0.88 | KDM4E (0.43) | ADRA2CKDRFLT1ABCB1ALDH1A1 | |
| SCHEMBL12461772 | 0.87 | ADRA2C (0.42) | ADRA2CKDRFLT1ABCB1ALDH1A1 | |
| SCHEMBL12461141 | 0.80 | ADRA2C (0.48) | ADRA2CKDRFLT1ALDH1A1KIT | |
| SCHEMBL12461142 | 0.80 | ADRA2C (0.42) | ADRA2CKDRFLT1ALDH1A1KIT | |
| SCHEMBL12461147 | 0.77 | KDR (0.41) | ADRA2CKDRFLT1ABCB1ALDH1A1 | |
| SCHEMBL1715401 | 0.77 | KDR (0.47) | ADRA2CKDRFLT1ABCB1ALDH1A1 | |
| SCHEMBL12461047 | 0.76 | KDR (0.48) | ADRA2CKDRFLT1KITABL1 | |
| SCHEMBL12461535 | 0.76 | KDR (0.51) | ADRA2CKDRFLT1ABCB1ALDH1A1 | |
| SCHEMBL1714888 | 0.76 | KDR (0.48) | ADRA2CKDRFLT1ABCB1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1697312-B1 | HYDROXAMIC ACID ESTERS AND PHARMACEUTICAL USE THEREOF | LEO PHARMA AS (DK) | 2011-07-20 | — | — | EP | disclosed |