Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14316337 | 0.90 | KDM4E (0.30) | KDM4EMEN1ALDH1A1HPGDKMT2A | |
| SCHEMBL28725 | 0.88 | KDM4E (0.42) | GPR119KDM4EMEN1ALDH1A1HPGD | |
| SCHEMBL2680078 | 0.87 | KDM4E (0.38) | GPR119KDM4EMEN1ALDH1A1HPGD | |
| SCHEMBL12461044 | 0.86 | CHRM2 (0.34) | KDM4EMEN1ALDH1A1HPGDKMT2A | |
| SCHEMBL2147497 | 0.86 | CHRM2 (0.34) | KDM4EMEN1ALDH1A1HPGDKMT2A | |
| SCHEMBL15807506 | 0.86 | CHRM2 (0.34) | KDM4EMEN1ALDH1A1HPGDKMT2A | |
| SCHEMBL2147530 | 0.86 | CHRM2 (0.34) | KDM4EMEN1ALDH1A1HPGDKMT2A | |
| SCHEMBL12460799 | 0.86 | CHRM2 (0.34) | KDM4EMEN1ALDH1A1HPGDKMT2A | |
| SCHEMBL12461398 | 0.86 | GPR119 (0.35) | GPR119KDM4EMEN1ALDH1A1HPGD | |
| SCHEMBL7880062 | 0.85 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011090935-A1 | PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS mTOR INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-07-28 | — | — | WO | disclosed |