Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | JMJD6 | Q6NYC1 | 9/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.36 |
| ▸ | CCR1 | P32246 | 1/20 | 0.35 |
| ▸ | CCR5 | P51681 | 1/20 | 0.35 |
| ▸ | CCR8 | P51685 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | SCN4A | P35499 | 1/20 | 0.34 |
| ▸ | CCNC | P24863 | 1/20 | 0.34 |
| ▸ | CDK8 | P49336 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.32 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20068615 | 0.78 | CCR1 (0.46) | CCR1CCR5CCR8HDAC6KDM4E | |
| SCHEMBL42126 | 0.78 | CCR1 (0.64) | KMT2AKEAP1JMJD6CYP19A1KDM5B | |
| SCHEMBL25324367 | 0.77 | KMT2A (0.42) | KMT2AKEAP1JMJD6CYP19A1KDM5B | |
| SCHEMBL28316565 | 0.77 | KEAP1 (0.58) | KMT2AKEAP1JMJD6CYP19A1KDM5B | |
| SCHEMBL30509507 | 0.77 | SCN4A (0.49) | KMT2AKEAP1JMJD6CYP19A1SCN4A | |
| SCHEMBL30509528 | 0.77 | KMT2A (0.42) | KMT2AKEAP1JMJD6CYP19A1KDM5B | |
| SCHEMBL2147232 | 0.77 | KMT2A (0.42) | KMT2AKEAP1JMJD6CYP19A1KDM5B | |
| SCHEMBL29972469 | 0.77 | KMT2A (0.42) | KMT2AKEAP1JMJD6CYP19A1KDM5B | |
| SCHEMBL18157906 | 0.76 | KMT2A (0.64) | KMT2AKEAP1JMJD6CYP19A1KDM5B | |
| SCHEMBL20086109 | 0.74 | CYP19A1 (0.45) | KMT2AKEAP1JMJD6CYP19A1SCN4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011090935-A1 | PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS mTOR INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-07-28 | — | — | WO | disclosed |